Ti-Catalyzed Multicomponent Oxidative Carboamination of Alkynes with Alkenes and Diazenes.
Ti-Catalyzed Multicomponent Oxidative Carboamination of Alkynes with Alkenes and Diazenes.
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DOI：
10.1021/jacs.6b09939
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发表时间：
2016-11-09
影响因子：
15
通讯作者：
Tonks IA
中科院分区：
文献类型：
--
作者：
Davis-Gilbert ZW;Yao LJ;Tonks IA
报道了以[py2TiCl2NPh]2为催化剂的炔烃分子间或分子内氧化碳胺化反应。这些多组分反应通过TiII/TiIV氧化还原循环将烯烃、炔烃和双氮烯偶联，形成α，β不饱和亚胺或α(亚氨甲基)环丙烷。这些产物中的每一个都由共同的氮杂环己烯中间体形成，该中间体经历β-H消除或α，γ偶联，其中选择性受底物控制。
The inter- or intramolecular oxidative carboamination of alkynes catalyzed by [py2TiCl2NPh]2 is reported. These multicomponent reactions couple alkenes, alkynes and diazenes to form either α,β-unsaturated imines or α-(iminomethyl)cyclopropanes via a TiII/TiIV redox cycle. Each of these products is formed from a common azatitanacyclohexene intermediate that undergoes either β-H elimination or α,γ-coupling, wherein the selectivity is under substrate control.