A review of the structure and function of the T-cell receptor-T3 complex.
A review of the structure and function of the T-cell receptor-T3 complex.
复制标题
T 细胞受体-T3 复合物的结构和功能综述。
DOI：
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发表时间：
1987
影响因子：
1.3
通讯作者：
C. Terhorst
中科院分区：
文献类型：
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作者：
H. Oettgen;C. Terhorst
在理解T细胞激活所涉及的事件中，最重要的是识别和表征相关的细胞表面分子。抗原诱导的刺激和随后的T细胞激活是通过与T细胞抗原受体的相互作用而启动的。许多证据表明T细胞抗原受体与T3密切相关，从而形成所谓的T3-T细胞受体复合体。首先，在使用抗T3单抗或抗T细胞受体抗体的免疫沉淀物中，已经检测到五条多肽链。这是两个二硫键桥联的可变糖蛋白(α和β链)和三个不变结构，分别是相对分子质量分别为25、20和20kdalton的T3-伽马链、β链和epsilon链。其次，经抗T3抗体和补体处理后，T白血病细胞系的突变体失去了表面的T3复合体，同时失去了克隆型异二聚体的表达。第三，针对T细胞受体α和β链或针对T3链的单抗以相同的方式影响T细胞功能。因此，我们看到T细胞受体和T3分子之间形成的复合体在功能和结构上都是免疫反应的中心。将讨论T3-T细胞受体复合体的结构、生物合成和基因表达的调节。将尝试将结构信息与T3-T细胞受体复合体的功能联系起来。
Of fundamental importance in understanding the events involved in T cell activation is the identification and characterization of the relevant cell surface molecules. Antigen-induced stimulation and subsequent activation of the T cell are initiated through interactions with the T cell antigen receptor. Several lines of evidence have demonstrated the intimate association between the T cell antigen receptor and T3, thus forming the so-called T3-T cell receptor complex. First, in immunoprecipitates with either anti-T3 monoclonal antibodies, or with anti-T cell receptor antibodies, five polypeptide chains have been detected. These are two disulfide bridged variable glycoproteins (alpha and beta chains) and three invariable structures the T3-gamma, delta, and epsilon chains with molecular weights of 25, 20, and 20 kdaltons, respectively. Second, mutants of a T leukemic cell line which were selected for the loss of the T3 complex from their surface by treatment with an anti-T3 antibody and complement concomitantly lost expression of the clonotypic heterodimer. Third, monoclonal antibodies directed at either the T cell receptor alpha and beta chains or at the T3 chains affect T cell functions in an identical fashion. Thus, we see that the complex formed between the T cell receptor and the T3 molecules is functionally as well as structurally central to the immune response. The structure, biosynthesis, and regulation of gene expression of the T3-T cell receptor complex will be discussed. An attempt will be made to relate the structural information to the function of the T3-T cell receptor complex.