Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats
Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats
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DOI：
10.1016/j.ejphar.2005.11.009
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发表时间：
2006-01-04
影响因子：
5
通讯作者：
Araki, H
中科院分区：
文献类型：
--
作者：
Li, B;Suemaru, K;Araki, H
电休克疗法被认为是治疗严重抑郁症的有效方法。我们已经证明，三环类抗抑郁药在大鼠强迫游泳试验中的抗抑郁样作用可被促肾上腺皮质激素（ACTH）重复治疗所阻断。在本研究中，我们研究了重复电惊厥刺激对强迫游泳试验和ACTH治疗大鼠脑源性神经营养因子（BDNF）蛋白水平的影响。在ACTH处理（100 μ g/大鼠，s.c.）每日一次，持续14天。在生理盐水和ACTH治疗的大鼠中，重复电惊厥刺激6或14天减少了强迫游泳试验中的不动时间，并增加了海马中BDNF蛋白水平。然而，重复丙咪嗪给药（10毫克/公斤，腹腔注射14天）没有影响ACTH治疗的大鼠海马BDNF蛋白水平。这些结果表明，电惊厥刺激有减少的影响，在强迫游泳试验中的三环抗抑郁药耐药抑郁模型大鼠反复ACTH治疗，并增加BDNF可能参与了这一现象。(c)2005 Elsevier B. V.保留所有权利。
Electroconvulsive therapy is considered to be an effective treatment for severe depression. We have already shown that the antidepressant-like effects of tricyclic antidepressants in the rat forced swim test are blocked by repeated treatment with adrenocorticotropic hormone (ACTH). In the present study, we investigated the effect of repeated electroconvulsive stimuli on the forced swim test and on brain-derived neurotrophic factor (BDNF) protein levels in ACTH-treated rats. Electroconvulsive stimuli (50 mA, 0.2 s) was administered 30 min after ACTH treatment (100 mu g/rat, s.c.) once daily for 14 days. In both saline and ACTH-treated rats, repeated electroconvulsive stimuli for 6 or 14 days decreased the immobility time in the forced swim test and increased the BDNF protein levels in the hippocampus. However, repeated imipramine administration (10 mg/kg, i.p. for 14 days) had no effect on the hippocampus BDNF protein levels in ACTH-treated rats. These results suggest that electroconvulsive stimuli has decreasing effects of immobility time in the forced swim test in the tricyclic antidepressant-resistant depressive model of rats induced by repeated ACTH treatment, and that increased BDNF may be involved in this phenomenon. (c) 2005 Elsevier B.V. All rights reserved.