Self-medication practices with antibiotics among Chinese university students
Self-medication practices with antibiotics among Chinese university students
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DOI：
10.1016/j.puhe.2015.04.005
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发表时间：
2016-01-01
期刊：
影响因子：
5.2
通讯作者：
Ba-Thein, W.
中科院分区：
文献类型：
--
作者：
Zhu, X.;Pan, H.;Ba-Thein, W.
目的：抗生素自我用药（SMA）是一个严重的全球健康问题。我们试图调查中国大学生的SMA行为和危险因素，并进一步探讨SMA行为与药物不良事件（ADEs）之间的关系。研究设计：横断面研究。方法：于2011年7月在江苏大学（JSU）采用预试问卷进行在线调查。结果：在2608名网站访问者中，1086名参与了调查（回复率为41.6%），426名受访者因不是JSU学生或重复参与而被排除，660名（占JSU学生的2.2%）被纳入分析，316名学生（47.9%）有终生SMA病史。在自我治疗的学生中，43.5%的人认为抗生素适合病毒性感染，65.9%的人在前一年发生过一次以上的SMA发作，73.5%的人至少使用过两种不同的抗生素，57.1%和64.4%的人在治疗过程中分别改变了抗生素的剂量和抗生素。女性性别、年龄较大和抗生素先验知识（PKA）被确定为SMA的独立危险因素。有PKA和没有PKA的学生在SMA频率、使用多种抗生素、切换抗生素剂量或抗生素方面没有差异。在自我用药的学生中，不良反应发生率为13.3%。频繁改变剂量和同时使用不同名称的同一抗生素是与ADE相关的独立风险行为。结论：我们的研究结果证实了中国大学生中存在较高的SMA患病率。年龄和PKA是中国大学生常见的独立SMA危险因素，女性是JSU学生独有的SMA危险因素。不良的SMA实践与ade相关。建议对抗生素销售进行严格管制，并通过进一步的医疗改革加强公众教育。(C) 2015年作者。Elsevier Ltd.出版。
Objectives: Self-medication with antibiotics (SMA) is a serious global health problem. We sought to investigate SMA behaviors and risk factors among Chinese university students, and further explore the association between SMA practices and adverse drug events (ADEs).Study design: Cross-sectional study.Methods: An online survey was conducted at Jiangsu University (JSU) in eastern China in July 2011 using a pretested questionnaire.Results: Out of 2608 website visitors, 1086 participated in the survey (response rate: 41.6%), 426 respondents were excluded for not being a JSU student or repeat participation, 660 (2.2% of JSU students) were included in analysis, and 316 students (47.9%) had a lifetime history of SMA. Among self-treated students, 43.5% believed that antibiotic was suitable for viral infections, 65.9% had more than one SMA episode in the previous year, 73.5% self-medicated with at least two different antibiotics, 57.1% and 64.4% changed antibiotic dosage and antibiotics during the course, respectively. Female gender, older age, and prior knowledge of antibiotics (PKA) were identified as independent risk factors of SMA. There was no difference between students with and without PKA regarding SMA frequency, use of polyantibiotics, and switching antibiotic dosage or antibiotics. ADEs happened to 13.3% of self-medicated students. Frequent change of dosage and simultaneous use of the same antibiotic with different names were independent risk practices associated with an ADE.Conclusions: Our findings substantiate high SMA prevalence among Chinese university students. Older age and PKA are independent SMA risk factors common to Chinese university students and female gender is exclusive SMA risk factor for JSU students. Poor SMA practices are associated with ADEs. Strict regulations on antibiotic sales and public education reinforced by further health care reform are recommended. (C) 2015 The Authors. Published by Elsevier Ltd.