Simulating Metaphyseal Fracture Healing in the Distal Radius
Simulating Metaphyseal Fracture Healing in the Distal Radius
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DOI：
10.3390/biomechanics1010003
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发表时间：
2021-06-01
期刊：
影响因子：
--
通讯作者：
Simon, Ulrich
中科院分区：
文献类型：
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作者：
Engelhardt, Lucas;Niemeyer, Frank;Simon, Ulrich
通过数值模型模拟骨干骨折愈合已经研究了很长时间。从体内研究中可以明显看出，干骺端骨折愈合应遵循相似的生物力学规则，尽管愈合速度和愈合模式可能不同。为了研究这一假设，一个预先存在的，完善的骨干骨折愈合模型被扩展到研究干骺端骨愈合。将桡骨远端骨折的临床数据与相应的几何学患者特异性骨折愈合模拟进行比较。数值模型，能够预测一个现实的骨折愈合过程中各种各样的半径几何形状。在骨折区域，预测软骨内骨化和主要膜内骨化，无骨痂形成。因此，该模型似乎适合于研究不同力学条件下的干骺端骨愈合和不同骨和骨折类型的干骺端骨折。然而，概述的模型是在简化的旋转对称情况下进行的。进一步的研究可能会将模型扩展到三维表示，以调查复杂的骨折形状。这将有助于优化桡骨骨折的临床治疗方法、医用植入物的设计以及促进干骺端骨折愈合的生物力学研究。
Simulating diaphyseal fracture healing via numerical models has been investigated for a long time. It is apparent from in vivo studies that metaphyseal fracture healing should follow similar biomechanical rules although the speed and healing pattern might differ. To investigate this hypothesis, a pre-existing, well-established diaphyseal fracture healing model was extended to study metaphyseal bone healing. Clinical data of distal radius fractures were compared to corresponding geometrically patient-specific fracture healing simulations. The numerical model, was able to predict a realistic fracture healing process in a wide variety of radius geometries. Endochondral and mainly intramembranous ossification was predicted in the fractured area without callus formation. The model, therefore, appears appropriate to study metaphyseal bone healing under differing mechanical conditions and metaphyseal fractures in different bones and fracture types. Nevertheless, the outlined model was conducted in a simplified rotational symmetric case. Further studies may extend the model to a three-dimensional representation to investigate complex fracture shapes. This will help to optimize clinical treatments of radial fractures, medical implant design and foster biomechanical research in metaphyseal fracture healing.