Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.
Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.
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DOI：
10.1084/jem.141.1.263
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发表时间：
1975-01-01
期刊：
影响因子：
--
通讯作者：
Benacerraf B
中科院分区：
文献类型：
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作者：
Katz DH;Graves M;Dorf ME;Dimuzio H;Benacerraf B
本研究的结果提供了令人信服的证据，在H-2基因复合物的指定I区存在控制最佳T-B细胞合作相互作用的基因。以前，我们推测，相关基因（S）很可能位于这个区域的基础上，从我们在这个领域的早期工作的几个观察（3，5，6）。因此，在前面的论文中，我们表明，T和B细胞从B10.BR和A株小鼠发展有效的合作相互作用，在体外DNP-KLH在一个系统相同的一个在此报告。由于这些小鼠在H-2的S和D区的基因不同，但K和I区基因相同，我们能够将关键基因定位到H-2的K端。
The results of this study provide compelling evidence for the existence of the gene or genes controlling optimal T-B-cell cooperative interactions in the designated I region of the H-2 gene complex. Previously, we have speculated that the relevant gene(s) involved may well be located in this region based on several observations from our earlier work in this area (3, 5, 6). Thus, in the preceding paper, we showed that T and B cells from B10.BR and A strain mice developed effective cooperative interactions in vitro to DNP-KLH in a system identical to the one reported herein. Since these mice differ for genes in the S and D regions of H-2 but are identical for K and I region genes, we were able to localize the critical genes to the K-end of H-2.