Residential proximity to livestock farms is associated with a lower prevalence of atopy
Residential proximity to livestock farms is associated with a lower prevalence of atopy
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DOI：
10.1136/oemed-2017-104769
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发表时间：
2018-06-01
影响因子：
4.9
通讯作者：
Smit, Lidwien A. M.
中科院分区：
文献类型：
--
作者：
Borlee, Floor;Yzermans, C. Joris;Smit, Lidwien A. M.
目标在童年和成年生活中接触农场环境似乎可以降低特应性过敏的风险。大多数研究都是在农民中进行的，但生活在农村地区的人们可能对特应性有类似的保护作用。本研究旨在调查居住在荷兰农村地区的非农业成年人中靠近畜牧场的住宅与特应性之间的关系。方法我们对 2443 名成年人（20-72 岁）进行了一项横断面研究。特应性定义为对常见过敏原的特异性 IgE 和/或总 IgE 100IU/mL。住宅与畜牧场的邻近度评估为 1) 与最近的猪、家禽、牛或任何农场的距离，2) 500m 和 1000m 范围内的农场数量，以及 3) 500m 和 1000m 范围内农场的模拟年平均细尘排放量。采用多元逻辑回归和广义相加模型对数据进行分析。结果特应性患病率为29.8%。居住在距离农场较近的受试者（527m，第三个三分位数）（OR 0.79，95%CI 0.63 至 0.98）。发现同一方向上与最近的猪场或牛场的距离存在显着关联。在农场长大的受试者中，特应性与畜牧场暴露之间的关联性更强。结论居住在畜牧场附近似乎可以预防特应性。这项研究提供的证据表明，生命早期和成年农场暴露的保护作用可能会延伸到农业人口之外。
ObjectivesExposure to farm environments during childhood and adult life seems to reduce the risk of atopic sensitisation. Most studies have been conducted among farmers, but people living in rural areas may have similar protective effects for atopy. This study aims to investigate the association between residential proximity to livestock farms and atopy among non-farming adults living in a rural area in the Netherlands.MethodsWe conducted a cross-sectional study among 2443 adults (20-72 years). Atopy was defined as specific IgE to common allergens and/or total IgE 100IU/mL. Residential proximity to livestock farms was assessed as 1) distance to the nearest pig, poultry, cattle or any farm, 2) number of farms within 500m and 1000m, and 3) modelled annual average fine dust emissions from farms within 500m and 1000m. Data were analysed with multiple logistic regression and generalised additive models.ResultsThe prevalence of atopy was 29.8%. Subjects living at short distances from farms (527m, third tertile) (OR 0.79, 95%CI 0.63 to 0.98). Significant associations in the same direction were found with distance to the nearest pig or cattle farm. The associations between atopy and livestock farm exposure were somewhat stronger in subjects who grew up on a farm.ConclusionsLiving in close proximity to livestock farms seems to protect against atopy. This study provides evidence that protective effects of early-life and adult farm exposures may extend beyond farming populations.