Pandemic and Avian Influenza A Viruses in Humans Epidemiology, Virology, Clinical Characteristics, and Treatment Strategy
Pandemic and Avian Influenza A Viruses in Humans Epidemiology, Virology, Clinical Characteristics, and Treatment Strategy
复制标题
DOI：
10.1016/j.ccm.2016.11.005
复制
发表时间：
2017-03-01
影响因子：
5.7
通讯作者：
Cao, Bin
中科院分区：
文献类型：
--
作者：
Li, Hui;Cao, Bin
流感大流行的间断性爆发和新型甲型禽流感病毒的出现是全球性的威胁。虽然大多数患者表现出轻微的症状，但有些患者会恶化为严重的肺炎，甚至死亡。世界范围内对疾病发病机制和一系列疫苗的认识取得了重大进展；然而，发病率、发病率和死亡率仍然很高。为了提高警惕和提高大流行防备，本文阐述了甲型流感病毒人类感染的病毒学、流行病学、发病机制、临床特征和治疗，重点介绍了甲型H1N1流感pdm09、H5N1和H7N9亚型。
The intermittent outbreak of pandemic influenza and emergence of novel avian influenza A virus is worldwide threat. Although most patients present with mild symptoms, some deteriorate to severe pneumonia and even death. Great progress in the understanding of the mechanism of disease pathogenesis and a series of vaccines has been promoted worldwide; however, incidence, morbidity, and mortality remains high. To step up vigilance and improve pandemic preparedness, this article elucidates the virology, epidemiology, pathogenesis, clinical characteristics, and treatment of human infections by influenza A viruses, with an emphasis on the influenza A(H1N1)pdm09, H5N1, and H7N9 subtypes.