The role of basement membranes in cardiac biology and disease.
The role of basement membranes in cardiac biology and disease.
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DOI：
10.1042/bsr20204185
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发表时间：
2021-08-27
影响因子：
4
通讯作者：
Van Agtmael T
中科院分区：
文献类型：
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作者：
Boland E;Quondamatteo F;Van Agtmael T
基底膜（BM）是高度特化的细胞外基质（ECM）结构，其在心脏内位于内皮细胞（EC）之下并围绕心肌细胞和血管平滑肌细胞。它们通过提供对底层间质的物理锚定、对组织的结构支持以及影响细胞行为和信号传导，在整个心脏发育和成熟过程中产生一个动态的、结构上支持的环境。虽然这提供了BM功能障碍和心脏疾病之间的强有力的联系，BM在心脏生物学中的作用仍然研究不足，我们对BM缺陷及其形态和功能后果之间的机制相互作用的理解仍然是重要的知识差距。在这篇综述中，我们汇集了对心脏内BM缺陷的新认识，包括常见的心血管病变，如收缩功能障碍，并强调了一些现在准备解决的关键问题。
Basement membranes (BMs) are highly specialised extracellular matrix (ECM) structures that within the heart underlie endothelial cells (ECs) and surround cardiomyocytes and vascular smooth muscle cells. They generate a dynamic and structurally supportive environment throughout cardiac development and maturation by providing physical anchorage to the underlying interstitium, structural support to the tissue, and by influencing cell behaviour and signalling. While this provides a strong link between BM dysfunction and cardiac disease, the role of the BM in cardiac biology remains under-researched and our understanding regarding the mechanistic interplay between BM defects and their morphological and functional consequences remain important knowledge-gaps. In this review, we bring together emerging understanding of BM defects within the heart including in common cardiovascular pathologies such as contractile dysfunction and highlight some key questions that are now ready to be addressed.