Factor V Leiden and prothrombin 20210 A mutations in patients with central and branch retinal vein occlusion
Factor V Leiden and prothrombin 20210 A mutations in patients with central and branch retinal vein occlusion
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DOI：
10.1034/j.1600-0420.1999.770602.x
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发表时间：
1999-12-01
期刊：
影响因子：
--
通讯作者：
Hasiripi, H
中科院分区：
文献类型：
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作者：
Kalayci, D;Gürgey, A;Hasiripi, H
目的：研究了 V 因子 Leiden 和凝血酶原 20210 A 突变在视网膜中央静脉阻塞 (CRVO)、半球视网膜静脉阻塞 (HRVO) 和视网膜分支静脉阻塞 (BRVO) 患者中的作用。方法：对从 52 例视网膜静脉阻塞患者的外周血中获得的 DNA 中的 V 因子 Leiden 和凝血酶原 20210 A 进行了研究。其中 25 名患者患有 CRVO 或 HRVO，27 名患者患有 BRVO。因子 V Leiden 和凝血酶原 20210 A 的对照组由两个独立组组成，每组分别为 81 名和 87 名健康人；分别对之前在 Hacettepe 大学血液学系进行过突变调查的个体，仅使用 Fisher 精确检验比较患者和对照组之间的 V 因子 Leiden 和凝血酶原 20210 A 突变频率。结果：在所有患者中 8%、CRVO-HRVO 组中 4% 和 BRVO 患者中 11% 发现 V 因子 Leiden 突变。在所有患者中均未发现凝血酶原 20210 A 突变。先前已在7%和2%的健康对照中发现了V因子Leiden和凝血酶原20210 A突变，患者和对照之间的频率差异无统计学意义。结论：尚未发现V因子Leiden和凝血酶原20210 A突变是任一类型视网膜静脉阻塞的危险因素。
Purpose: The role of factor V Leiden and prothrombin 20210 A mutations has been investigated in patients with central retinal vein occlusion (CRVO), hemispheric retinal vein occlusion (HRVO), and branch retinal vein occlusion (BRVO).Methods: Factor V Leiden and prothrombin 20210 A were investigated in DNA obtained from the peripheral blood of 52 patients with retinal vein occlusion, Twenty-five of the patients had either CRVO or HRVO, and 27 patients had BRVO, The control groups for factor V Leiden and prothrombin 20210 A were comprised of two separate groups of 81 and 87 healthy; individuals, respectively who had been previously investigated for the mutations at Hacettepe University Department of Hematology, The frequencies of factor V Leiden and prothrombin 20210 A mutations mere compared between the patients and the controls using Fisher's exact test.Results: Factor V Leiden mutation was found in 8% of all patients, 4% of the CRVO-HRVO group and 11% of the BRVO patients. Prothrombin 20210 A mutation was not found in any of the patients. Factor V Leiden and prothrombin 20210 A mutations have been previously found in 7% and 2% of the healthy controls, respectively The differences of frequencies between the patients and the controls mere not statistically significant.Conclusion: Factor V Leiden and prothrombin 20210 A mutations have not been found to be risk factors in either type of retinal vein occlusion.