Risk factors for severe respiratory syncytial virus infection among Alaska Native children

Risk factors for severe respiratory syncytial virus infection among Alaska Native children
复制标题

DOI：
10.1542/peds.109.2.210
复制
发表时间：
2002-02-01
期刊：
PEDIATRICS
影响因子：
8
通讯作者：
Harrison, LH
Harrison, LH
中科院分区：
医学2区
文献类型：
--
作者：
Bulkow, LR;Singleton, RJ;Harrison, LH

文献摘要

被引文献

相似文献

Objective.在美国，阿拉斯加原住民儿童因呼吸道合胞病毒（RSV）感染住院的发病率远高于非原住民人口。我们进行这项研究是为了更好地了解高危人群中RSV感染导致住院的相关因素。病例对照研究，包括采集脐带血用于RSV中和抗体测定。阿拉斯加西南部偏远地区，由1家地区医院和2家转诊医院提供服务。通过RSV感染监测确定的病例-患者和匹配的对照受试者，无急性呼吸道感染住院。母乳喂养与RSV住院风险较低相关（比值比：0.34），而基础疾病（主要是早产）与风险增加相关（比值比：6.25）。与住院风险较高相关的环境因素包括家庭拥挤（家庭中有4个或更多儿童，拥挤指数>2）。结论母亲RSV中和抗体水平与住院风险无关。在RSV住院风险极高的这一地区，鼓励母乳喂养和减少家庭拥挤等几项措施可以降低RSV导致的住院风险。
Objective. The incidence of hospitalization for respiratory syncytial virus (RSV) infection among Alaska Native children is much higher than among non-Native populations in the United States. We conducted this study to better understand factors associated with hospitalization attributable to RSV infection in this high-risk population.Design. Case-control study, including collection of cord blood for RSV-neutralizing antibody measurement.Setting. Remote region of southwest Alaska served by 1 regional hospital and 2 referral hospitals.Subjects. Case-patients identified through surveillance for RSV infection and matched control subjects without acute respiratory infection hospitalization.Results. Breastfeeding was associated with a lower risk of RSV hospitalization (odds ratio: 0.34), whereas underlying medical conditions (primarily prematurity) were associated with increased risk (odds ratio: 6.25). Environmental factors associated with a higher risk of hospitalization included household crowding (4 or more children in the household and crowding index >2). The level of maternal RSV-neutralizing antibody was not associated with the risk of hospitalization.Conclusions. In this region with extremely high risk of RSV hospitalization, several measures, such as encouraging breastfeeding and reducing household crowding, could reduce the risk of hospitalization attributable to RSV.