Chemical genetics and strigolactone perception.
Chemical genetics and strigolactone perception.
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DOI：
10.12688/f1000research.11379.1
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
McCourt P
中科院分区：
文献类型：
--
作者：
Lumba S;Bunsick M;McCourt P
独脚金内酯 (SL) 是一系列相关小分子的集合，在植物生长和发育中充当激素。有趣的是，SL 还充当植物和菌根真菌之间以及寄主植物和寄生植物物种集合之间的生态通讯者。对于菌根真菌，SL 从宿主根部渗出到土壤中，吸引真菌菌丝进行有益的相互作用。然而，对于寄生植物来说，根部分泌的 SL 会导致休眠的寄生植物种子发芽，从而使产生的幼苗感染宿主并吸收营养。由于寄生植物不存在适合实验室的模型，研究人员目前正在利用从拟南芥等模型植物中收集的信息，结合通过化学遗传学开发的化学探针来了解寄生植物的 SL 感知。这项工作首先表明，了解 SL 信号传导有助于开发扰乱 SL 感知的化学探针。其次，它表明可用于探测模型植物和寄生植物中 SL 信号传导的化学空间相当大。由于这些寄生害虫是发展中国家粮食不安全的主要问题，因此非常需要化学方法来发现干扰寄生植物感染的新型铅化合物。
Strigolactones (SLs) are a collection of related small molecules that act as hormones in plant growth and development. Intriguingly, SLs also act as ecological communicators between plants and mycorrhizal fungi and between host plants and a collection of parasitic plant species. In the case of mycorrhizal fungi, SLs exude into the soil from host roots to attract fungal hyphae for a beneficial interaction. In the case of parasitic plants, however, root-exuded SLs cause dormant parasitic plant seeds to germinate, thereby allowing the resulting seedling to infect the host and withdraw nutrients. Because a laboratory-friendly model does not exist for parasitic plants, researchers are currently using information gleaned from model plants like Arabidopsis in combination with the chemical probes developed through chemical genetics to understand SL perception of parasitic plants. This work first shows that understanding SL signaling is useful in developing chemical probes that perturb SL perception. Second, it indicates that the chemical space available to probe SL signaling in both model and parasitic plants is sizeable. Because these parasitic pests represent a major concern for food insecurity in the developing world, there is great need for chemical approaches to uncover novel lead compounds that perturb parasitic plant infections.