ROLE OF DIET FAT IN SUBCELLULAR STRUCTURE AND FUNCTION
ROLE OF DIET FAT IN SUBCELLULAR STRUCTURE AND FUNCTION
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DOI：
10.1139/y85-094
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发表时间：
1985-01-01
影响因子：
2.1
通讯作者：
ZSIGMOND, E
中科院分区：
文献类型：
--
作者：
CLANDININ, MT;FIELD, CJ;ZSIGMOND, E
目前关于生物膜的概念将被外推到恒温动物的膜上，以说明营养完整的饮食中膳食脂肪的性质对膜的极性头基含量和脂肪酸组成的影响。利用动物模型，可以证明饮食中长链脂肪酸对心脏组织线粒体膜、肝脏质膜和脑突触体膜主要脂类组分的控制作用。饮食诱导的膜成分变化与特定膜蛋白功能的明显变化有关。为了说明这种关系，将讨论饮食对线粒体ATPase活性和肝脏质膜激素受体刺激功能的影响。这些观察表明，饮食脂肪通过改变膜中周围的脂质环境来调节活体中的酶功能。
Current concepts of the biomembrane will be extrapolated to membranes of homeotherms to illustrate the influence of the nature of dietary lipid in nutritionally complete diets on membrane polar head group content and fatty acid composition. Utilizing animal models, the controlling influence of dietary long chain fatty acids on major lipid constituents of the mitochondrial membrane in cardiac tissue, the plasma membrane of liver, and the synaptosomal membrane in brain can be demonstrated. Diet-induced alterations in membrane composition arc associated with demonstrable changes in the function of specific membrane proteins. To illustrate this relationship, the effect of diet on mitochondrial ATPase activity and on a hormone receptor-stimulated function in the plasma membrane of the liver will be discussed. These observations suggest that the diet fat modulates enzyme functionsin vivoby changing the surrounding lipid environment in the membrane.