Abnormal glucose metabolism in the anterior cingulate cortex in patients with schizophrenia
Abnormal glucose metabolism in the anterior cingulate cortex in patients with schizophrenia
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DOI：
10.1016/j.pscychresns.2006.04.002
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发表时间：
2007-01-15
影响因子：
2.3
通讯作者：
Kato, Nobumasa
中科院分区：
文献类型：
--
作者：
Fujimoto, Toshiro;Takeuch, Kouzou;Kato, Nobumasa
使用[F-18]氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）研究了接受精神安定药治疗的精神分裂症患者大脑中葡萄糖代谢的变化。对三四十岁的 14 名男性和 8 名女性患者进行了静息状态的研究。 FDG-PET 数据采用解剖标准化方法、三维立体表面投影 (3D-SSP) 进行处理，提供相对葡萄糖代谢值，减轻脑萎缩的污染。还获得了表明患者和对照组之间代谢差异的 Z 分数图。对左右半球 19 个区域的代谢值进行了评估。患者的额叶皮层、初级感觉区和前扣带皮层的代谢值下降，两个半球的头侧情感分区比背侧认知分区下降更多，而左右基底神经节、左颞叶和右顶叶内侧区的代谢值增加。男性患者的两个前扣带回区域的值均比女性患者下降更多，右侧丘脑的值增加更多，这表明精神分裂症患者的前扣带回和丘脑存在与性别相关的功能障碍。 FDG-PET 证明精神分裂症可能是一种额叶-纹状体-丘脑回路（包括扣带皮层）功能障碍的疾病。 (c) 2006 Elsevier Ireland Ltd. 保留所有权利。
Changes in glucose metabolism were studied in the brains of schizophrenic patients treated with neuroleptics, using [F-18]fluorodeoxy-glucose positron emission tomography (FDG-PET). Fourteen male and eight female patients in their thirties and forties were studied in a resting state. Data from FDG-PET were processed with an anatomic standardization method, three-dimensional stereotactic surface projections (3D-SSP), which provided relative glucose metabolic values that mitigated the contamination of brain atrophy. Z-score maps indicating metabolic differences between the patient and control groups were also acquired. Metabolic values in 19 regions were evaluated in the right and left hemispheres. Patients showed decreased values in the frontal cortex, primary sensory regions, and anterior cingulate cortex, more in the rostral affective subdivision than the dorsal cognitive subdivision in both hemispheres, and increased metabolic values in left and right basal ganglia, left temporal and right medial parietal regions. Values were more decreased in both anterior cingulate regions, and more increased in the right thalamus in male than female patients, suggesting gender-related dysfunction in the anterior cingulate and thalamus in schizophrenia. FDG-PET demonstrated that schizophrenia may be a disorder with a dysfunction of fronto-striatal-thalamic circuitry including the cingulate cortex. (c) 2006 Elsevier Ireland Ltd. All rights reserved.