Weak Bond-Based Injectable and Stimuli Responsive Hydrogels for Biomedical Applications.
Weak Bond-Based Injectable and Stimuli Responsive Hydrogels for Biomedical Applications.
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DOI：
10.1039/c6tb03052a
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发表时间：
2017-02-07
期刊：
影响因子：
--
通讯作者：
Wang Y
中科院分区：
文献类型：
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作者：
Ding X;Wang Y
在这里，我们定义弱键交联的水凝胶为物理水凝胶。它们具有独特的功能，包括可逆键合，剪切变稀和刺激响应性。与共价交联的水凝胶不同，物理水凝胶不需要引发剂来引发原位凝胶化的化学反应。药物可以完全装载在预成型的水凝胶中，用于在注射期间以最小的货物泄漏递送。这些优点使得物理水凝胶可用作生物医学工程中应用的递送载体。本文综述了通过弱键交联的物理水凝胶的研究进展，这些弱键包括氢键、离子相互作用、主-客体化学、疏水相互作用、配位键和π-π堆积相互作用。了解具有这些动态键的凝胶的原理和最新技术水平可能会在许多生物医学研究领域（包括药物递送和组织工程）取得突破。
Here we define hydrogels crosslinked by weak bonds as physical hydrogels. They possess unique features including reversible bonding, shear thinning and stimuli-responsiveness. Unlike covalently crosslinked hydrogels, physical hydrogels do not require triggers to initiate chemical reactions for in situ gelation. The drug can be fully loaded in a pre-formed hydrogel for delivery with minimal cargo leakage during injection. These benefits make physical hydrogels useful as delivery vehicles for applications in biomedical engineering. This review focuses on recent advances of physical hydrogels crosslinked by weak bonds: hydrogen bonds, ionic interactions, host-guest chemistry, hydrophobic interactions, coordination bonds and π-π stacking interactions. Understanding the principles and the state of the art of gels with these dynamic bonds may give rise to breakthroughs in many biomedical research areas including drug delivery and tissue engineering.