ELOVL2: Not just a biomarker of aging.
ELOVL2: Not just a biomarker of aging.
复制标题
ELOVL2：不仅仅是衰老的生物标志物。
DOI：
10.1016/j.tma.2020.06.004
复制
发表时间：
2020
影响因子：
--
通讯作者：
Skowronska-Krawczyk D
中科院分区：
文献类型：
--
作者：
Chao DL;Skowronska-Krawczyk D
DNA methylation of the ELOVL2 (Elongation Of Very Long Chain Fatty Acids-Like 2) promoter is one of the most robust molecular biomarkers for chronological age, but whether ELOVL2 plays a functional role in aging has not been explored. ELOVL2 encodes a transmembrane protein involved in the synthesis of very long polyunsaturated fatty acids (VLC-PUFAs). These fatty acids play important roles in retinal biology and photoreceptor renewal, key processes implicated in age-related eye diseases such as age-related macular degeneration (AMD). Here, we summarize our work deciphering the role of ELOVL2 in the eye emphasizing the potential functional role of age-related DNA methylation in the pathophysiology of AMD.
