Caffeine therapy in preterm infants.
Caffeine therapy in preterm infants.
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DOI：
10.5409/wjcp.v4.i4.81
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发表时间：
2015-11-08
期刊：
影响因子：
--
通讯作者：
Nour, Islam
中科院分区：
文献类型：
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作者：
Abdel-Hady, Hesham;Nasef, Nehad;Nour, Islam
咖啡因是治疗早产儿呼吸暂停最常用的药物。其在降低机械通气早产儿呼吸暂停、间歇性低氧血症和拔管失败的频率方面的作用已得到充分证实。也有证据表明，在降低支气管肺发育不良和动脉导管未闭的发生率方面有额外的短期获益。新生儿重症监护病房对甲基黄嘌呤类药物的疗效、给药方案、用药时间、治疗持续时间、药物安全性及治疗药物监测价值等方面存在争议。在目前的审查中，我们将总结现有的证据，在早产儿中使用咖啡因治疗的最佳实践。
Caffeine is the most commonly used medication for treatment of apnea of prematurity. Its effect has been well established in reducing the frequency of apnea, intermittent hypoxemia, and extubation failure in mechanically ventilated preterm infants. Evidence for additional short-term benefits on reducing the incidence of bronchopulmonary dysplasia and patent ductus arteriosus has also been suggested. Controversies exist among various neonatal intensive care units in terms of drug efficacy compared to other methylxanthines, dosage regimen, time of initiation, duration of therapy, drug safety and value of therapeutic drug monitoring. In the current review, we will summarize the available evidence for the best practice in using caffeine therapy in preterm infants.