Relationship between bone mineralization and aluminium in the healthy infant
Relationship between bone mineralization and aluminium in the healthy infant
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DOI：
10.1038/sj.ejcn.1600582
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发表时间：
1998-06-01
影响因子：
4.7
通讯作者：
Duhamel, JF
中科院分区：
文献类型：
--
作者：
Bougle, D;Sabatier, JP;Duhamel, JF
目的：这项前瞻性研究旨在评估健康早产儿（PT）和足月儿（FT）血清铝水平变化与骨矿化（其靶组织之一）之间的关系。研究设计：用双能X线骨密度仪测定腰椎骨密度（BMD）和骨矿含量（BMC），并与血清铝（S-AI）、钙（S-Ca）、磷（S-P）、骨钙素、通过简单和多元回归分析，在出院后的健康PT（n = 44）和FT（n = 82）中测定碱性磷酸酶活性（S-AP）和25 OH维生素D（25 OH D）。PT（出生时胎龄（平均值+/- 1 s.d.）32 +/- 2周龄）和FT分别为43 +/- 39和36 +/- 32周龄。在包括出生时胎龄的PT多元逐步回归分析中，在孕龄和出生后年龄中，BMD和BMC与出生后年龄呈显著相关，与S-Al呈负相关，而在FT中，BMD和BMC与年龄和S-Ca呈显著相关。在PT中，血液Al的变化与发育迟缓相关。即使是健康的PT婴儿，也应注意降低铝水平。
Objective: This prospective study was designed to assess the relationship between variations of serum Aluminium levels and bone mineralization, which is one of its target tissues, in healthy premature (PT) and fullterm (FT) infants.Study design: Lumbar spine bone mineral density (BMD) and content (BMC) studied by dual energy X-ray absorptiometry were compared to serum aluminium (S-AI), Ca (S-Ca), P (S-P), osteocalcin, alkaline phosphatase activity (S-AP), and 25 OH Vitamin D (25 OH D) by simple and multiple regressions in healthy PT (n = 44) following their hospital discharge and FT (n = 82). PT (gestational age at birth (mean +/- 1 s.d.) 32 +/- 2 weeks) and FT were 43 +/- 39 and 36 +/- 32 weeks old respectively.Results: In PT multiple stepwise regression analysis including gestational age at birth, postconceptional age and postnatal age displayed only a significant correlation between BMD or BMC and postnatal age and a negative one with S-Al. In FT correlations were found between BMD or BMC and age and S-Ca.Conclusions: In PT, variations in blood Al are associated with developmental delays. Care should be taken to lessen Al levels, even in healthy PT babies.