Gö6983 attenuates breast cancer‐induced osteolysis by the apoptotic pathway
Gö6983 attenuates breast cancer‐induced osteolysis by the apoptotic pathway
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Gö6983 通过细胞凋亡途径减轻乳腺癌诱导的骨溶解
DOI：
10.1002/cbin.11281
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发表时间：
2020
影响因子：
3.9
通讯作者：
Jun Yao
中科院分区：
文献类型：
--
作者：
Zhiwei Luan;Jia Li;Xing Huang;Wenyu Feng;Shiting Ma;Fengyang Song;Zhengyuan Wu;Xiaohan Zhang;Linfeng Wei;Zhenyi Yang;Jun Yao
乳腺癌引起的骨转移导致治疗中的严重并发症，并且由此产生的骨质溶解相当大地影响患者的总体生存和生活质量。Gö 6983是一种广谱蛋白激酶C抑制剂。在这项研究中，基于我们发现Gö 6983抑制骨质溶解，我们将Gö 6983应用于MDA-MB-231乳腺癌诱导的小鼠骨转移模型。我们发现Gö 6983通过促进线粒体凋亡途径对乳腺癌致瘤模型具有较强的抑制作用。因此，我们的研究表明Gö 6983对乳腺癌诱导的破骨细胞激活具有潜在的抑制作用，并提供了可能对设计未来治疗方法有用的机制见解。
Bone metastasis caused by breast cancer leads to significant complications in treatment, and the resulting osteolysis considerably affects patients’ overall survival and quality of life. Gö6983 is a broad spectrum protein kinase C inhibitor. In this study, based on our finding that the Gö6983 inhibits osteolysis, we applied Gö6983 to the MDA‐MB‐231 breast cancer‐induced mouse bone metastasis model. And we found that Gö6983 has a strong inhibitory effect on the tumorigenic model of breast cancer by promoting the mitochondrial apoptosis pathway. Our study, therefore, demonstrates that Gö6983 has a potential inhibitory effect on breast cancer‐induced osteoclast activation and provides mechanistic insight that may prove useful for designing future treatments.