Frequency preference and attention effects across cortical depths in the human primary auditory cortex
Frequency preference and attention effects across cortical depths in the human primary auditory cortex
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DOI：
10.1073/pnas.1507552112
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发表时间：
2015-12-29
影响因子：
11.1
通讯作者：
Formisano, Elia
中科院分区：
文献类型：
--
作者：
De Martino, Federico;Moerel, Michelle;Formisano, Elia
具有相似偏好的神经元的柱状排列被认为是大脑皮层的基本处理单位。在这些柱状排列中，前馈信息进入中层大脑皮层，而反馈信息进入浅层和深层。这种前馈和反馈处理的相互作用是感知和行为的核心。在这里，我们提供了与人类听觉皮质中处理声音频率的柱状组织一致的活体证据。我们测量了在强磁场(7特斯拉)下对声频率扫描的亚毫米功能反应，并表明频率偏好通过初级听觉皮质的皮质深度是稳定的。此外，我们证明--在这个高度柱状的皮层--任务要求使皮层浅层的频率调谐比中层或深层的频率调谐更尖锐。这些发现对于理解声音主动感知过程中神经信息处理和流动的机制是至关重要的。
Columnar arrangements of neurons with similar preference have been suggested as the fundamental processing units of the cerebral cortex. Within these columnar arrangements, feed-forward information enters at middle cortical layers whereas feedback information arrives at superficial and deep layers. This interplay of feed-forward and feedback processing is at the core of perception and behavior. Here we provide in vivo evidence consistent with a columnar organization of the processing of sound frequency in the human auditory cortex. We measure submillimeter functional responses to sound frequency sweeps at high magnetic fields (7 tesla) and show that frequency preference is stable through cortical depth in primary auditory cortex. Furthermore, we demonstrate that-in this highly columnar cortex-task demands sharpen the frequency tuning in superficial cortical layers more than in middle or deep layers. These findings are pivotal to understanding mechanisms of neural information processing and flow during the active perception of sounds.