Accessibility and the developmental regulation of V(D)J recombination.
Accessibility and the developmental regulation of V(D)J recombination.
复制标题
DOI：
10.1006/smim.1997.0066
复制
发表时间：
1997-06-01
影响因子：
7.8
通讯作者：
Stanhope-Baker, P
中科院分区：
文献类型：
--
作者：
Schlissel, M S;Stanhope-Baker, P
抗原受体基因是通过一系列高度调控的位点特异性DNA重组反应（称为V（D）J重组）从其组分基因片段组装而成的。由RAG1和RAG2基因编码的蛋白质负责识别和双链切割位于所有重排基因片段侧翼的高度保守DNA序列。目前还不清楚这种常见的淋巴重组酶是如何靶向发育中的B和T细胞的不同位点以及淋巴细胞发育的连续阶段的特定位点的。这篇评论认为，DNA序列调节抗原受体基因的转录也调节重组反应，通过确定单个位点的V（D）J重组酶的可及性的证据。
Antigen receptor genes are assembled from their component gene segments by a highly regulated series of site-specific DNA recombination reactions known as V(D)J recombination. Proteins encoded by the RAG1 and RAG2 genes are responsible for the recognition and double-stranded cleavage of a highly conserved DNA sequence flanking all rearranging gene segments. It remains uncertain how this common lymphoid recombinase is targeted to distinct loci in developing B and T cells and to specific loci at successive stages of lymphocyte development. This review considers evidence that DNA sequences which regulate the transcription of antigen receptor genes also regulate the recombination reaction by determining the accessibility of individual loci to the V(D)J recombinase.