Early peanut introduction wins over the HLA-DQA1*01:02 allele in the interplay between environment and genetics.
Early peanut introduction wins over the HLA-DQA1*01:02 allele in the interplay between environment and genetics.
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DOI：
10.1172/jci155609
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发表时间：
2022-01-04
期刊：
影响因子：
--
通讯作者：
Kasowski M
中科院分区：
文献类型：
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作者：
Manohar M;Nadeau KC;Kasowski M
儿童食物过敏发病率的上升突显了环境暴露的重要性；然而，遗传因素发挥了主要作用。环境和遗传是如何相互作用导致食物过敏的尚不清楚。具有里程碑意义的早期学习花生过敏(LEAP)临床试验证实，早期引入花生可以保护高危婴儿，这与肠道暴露的耐受效果一致。在这一期的《少年警讯》中，坎坎等人。利用LEAP试验数据来检查早期致敏的分子遗传机制。先前发现的花生过敏的人类白细胞抗原风险等位基因(DQA1*01：02)与消费者中花生特异性IgG4水平有关。值得注意的是，IgG4抗体可能通过减少过敏原与IgE的结合来提供保护。在避孕者中，相同的等位基因与花生过敏之间的关联，同时可能为消费者提供保护，这强化了将遗传信息整合到个性化治疗策略中的必要性，以期在解决食物过敏问题上取得最佳结果。
The rising incidence of food allergy in children underscores the importance of environmental exposures; however, genetic factors play a major role. How the environment and genetics interact to cause food allergy remains unclear. The landmark Learning Early About Peanut Allergy (LEAP) clinical trial established that early peanut introduction protects high-risk infants, consistent with the tolerizing effects of gut exposure. In this issue of the JCI, Kanchan et al. leveraged the LEAP trial data to examine molecular genetic mechanisms of early sensitization. A previously identified HLA risk allele for peanut allergy (DQA1*01:02) was associated with peanut-specific IgG4 levels in consumers. Notably, IgG4 antibodies likely provide protection by reducing the binding of allergen to IgE. The association of the same allele with peanut allergy in avoiders while potentially conferring protection in consumers reinforces the need to integrate genetic information toward a personalized therapeutic strategy for the best outcome in addressing food allergies.