Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories
Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories
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DOI：
10.1038/nature04053
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发表时间：
2005-10-20
期刊：
影响因子：
64.8
通讯作者：
Graybiel, AM
中科院分区：
文献类型：
--
作者：
Barnes, TD;Kubota, Y;Graybiel, AM
学习执行行为程序作为一种根深蒂固的习惯需要大量重复的行为序列，而学习不执行这些行为是非常困难的。然而，重新养成一种习惯可以很快发生，即使是一个或几个接触到以前触发行为的线索（1-3）。为了确定可能构成这种学习动力学基础的神经机制，我们对大鼠的感觉运动纹状体（一种与习惯形成有关的基底神经节结构）中的多个神经元进行了长期记录（4-8），这些大鼠先后接受了基于奖励的程序性任务训练、消退训练和重新获取训练。纹状体输出神经元，皮质基底神经节回路的节点，在这些学习阶段的每个阶段，在多个维度上发生显着变化。首先，新的任务相关的集体发射模式先后形成，逆转，然后重新出现。第二，与任务无关的激发被抑制，然后反弹，然后再次被抑制。这些变化的尖峰活动模式与行为表现的变化高度相关。我们提出，这些变化在皮质基底神经节电路的任务表示的探索，利用习惯学习的行为特征的神经等价物。
Learning to perform a behavioural procedure as a well-ingrained habit requires extensive repetition of the behavioural sequence, and learning not to perform such behaviours is notoriously difficult. Yet regaining a habit can occur quickly, with even one or a few exposures to cues previously triggering the behaviour(1-3). To identify neural mechanisms that might underlie such learning dynamics, we made long-term recordings from multiple neurons in the sensorimotor striatum, a basal ganglia structure implicated in habit formation(4-8), in rats successively trained on a reward-based procedural task, given extinction training and then given reacquisition training. The spike activity of striatal output neurons, nodal points in cortico-basal ganglia circuits, changed markedly across multiple dimensions during each of these phases of learning. First, new patterns of task-related ensemble firing successively formed, reversed and then re-emerged. Second, task-irrelevant firing was suppressed, then rebounded, and then was suppressed again. These changing spike activity patterns were highly correlated with changes in behavioural performance. We propose that these changes in task representation in cortico-basal ganglia circuits represent neural equivalents of the explore-exploit behaviour characteristic of habit learning.