Peripheral NMDA receptor modulation of jaw muscle electromyographic activity induced by capsaicin injection into the temporomandibular joint of rats
Peripheral NMDA receptor modulation of jaw muscle electromyographic activity induced by capsaicin injection into the temporomandibular joint of rats
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DOI：
10.1016/j.brainres.2005.03.040
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发表时间：
2005-06-07
期刊：
影响因子：
2.9
通讯作者：
Hu, JW
中科院分区：
文献类型：
--
作者：
Lam, DK;Sessle, BJ;Hu, JW
我们先前已经证明，外周N-甲基-D-天冬氨酸（NMDA）受体机制参与伤害性反射增加颌肌活动的芥子油或谷氨酸注射到大鼠颞下颌关节（TMJ）。本研究的目的是确定是否外周NMDA受体mechanisms也参与了在颌肌的伤害性反射反应诱发的炎症刺激和镇痛化学辣椒素注入颞下颌关节。在氟烷麻醉的雄性大鼠上，研究了外周注射NMDA受体拮抗剂MK-801和APV对颞下颌关节内注射辣椒素引起的二腹肌和咬肌反射性肌电活动增加的影响。在预注射媒介物之后注射辣椒素诱发二腹肌和咬肌中的EMG活动的显著增加，而将MK-801或APV预注射到TMJ中导致辣椒素诱发的二腹肌和咬肌EMG活动的幅度的显著浓度相关性降低（等级上的ANOVA，P < 0.05）。这一发现表明，辣椒素诱发的二腹肌和咬肌肌电活动可以通过预先注射到颞下颌关节的NMDA受体拮抗剂衰减，外周NMDA受体的激活可能是重要的机制，辣椒素引起伤害性三叉神经反应。(c)2005 Elsevier B. V.保留所有权利。
We have previously documented that peripheral N-methyl-D-aspartate (NMDA) receptor mechanisms are involved in nociceptive reflex increases in jaw muscle activity to injection of mustard oil or glutamate into the rat temporomandibular joint (TMJ). The aim of the present study was to determine whether peripheral NMDA receptor rnechanisms are also involved in the nociceptive reflex responses in the jaw muscles evoked by injection of the inflammatory irritant and algesic chemical capsaicin into the TMJ. The effects of peripheral injection of NMDA receptor antagonists, MK-801 and APV, on the increases in electromyographic (EMG) activities of digastric and masseter muscles reflexly evoked by capsaicin injection into the TMJ were tested in halothane-anesthetized male rats. The capsaicin injection following pre-injection of vehicle evoked significant increases in EMG activity in both digastric and masseter muscles whereas pre-injection of MK-801 or APV into the TMJ resulted in a significant concentration-related reduction in the magnitude of capsaicin -evoked digastric and masseter EMG activity (ANOVA-on-ranks, P < 0.05). This finding indicates that capsaicin-evoked digastric and masseter EMG activity can be attenuated by pre-injection into the TMJ of NMDA receptor antagonists, and that the activation of peripheral NMDA receptors may be important in the mechanisms whereby capsaicin evokes nociceptive trigeminal responses. (c) 2005 Elsevier B.V. All rights reserved.