NEW KNOWLEDGE IN HUMAN MILK IMMUNOGLOBULIN
NEW KNOWLEDGE IN HUMAN MILK IMMUNOGLOBULIN
复制标题
人乳免疫球蛋白的新知识
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
Edén Cs
中科院分区：
文献类型：
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作者：
L. Hanson;S. Ahlstedt;B. Carlsson;S. ;B. Kaijser;B. Lindblad;Akerlund As;Edén Cs
摘要。母乳的抗感染原理之一是主要的乳汁免疫球蛋白，分泌伊加。这种免疫球蛋白含有针对许多病原体和潜在病原体、病毒以及细菌的抗体，包括肠杆菌属的几个成员，这些牛奶抗体的抗原刺激似乎发生在肠道的Peyer集合淋巴结中。在抗原暴露后离开斑块的类淋巴细胞似乎通过淋巴和血液循环回到乳腺。因此，乳汁中含有分泌型伊加抗体，其中包括针对母亲肠道细菌的抗体。这些母乳抗体可能反映了社区中的细菌和病毒谱，对保护母乳喂养的婴儿可能很重要。通过相同的归巢机制，母乳获得针对饮食抗原（包括牛奶蛋白）的抗体。对混合喂养婴儿的研究表明，针对牛蛋白的分泌型伊加抗体减少了抗原暴露，表明抗过敏机制的可能性。
ABSTRACT. One of the anti‐infection principles of maternal milk is the predominant milk immunoglobulin, secretory IgA. This immunoglobulin contains antibodies against many pathogens and potential pathogens, viruses as well as bacteria, including several members of Enterobacteriacae, The antigenic stimuli for these milk antibodies seem to take place in the Peyer's patches of the intestine. Lymphoid cells leaving the patches after antigenic exposure seem to home to the mammary glands via the lymph and blood circulation. As a result, the milk contains secretory IgA antibodies against, among other things, the intestinal bacteria of the mother. These milk antibodies might reflect the spectrum of bacteria and viruses in the community and may be important for the protection of the breast‐fed baby. Via the same homing mechanism the maternal milk obtains antibodies against dietary antigens, including cow's milk proteins. Studies of infants on mixed feeding suggest that the secretory IgA antibodies against the bovine proteins diminish the antigenic exposure, indicating the possibility of an anti‐allergic mechanism.