Anthelmintic activity of Croton zehntneri and Lippia sidoides essential oils
Anthelmintic activity of Croton zehntneri and Lippia sidoides essential oils
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DOI：
10.1016/j.vetpar.2007.06.012
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发表时间：
2007-09-30
影响因子：
2.6
通讯作者：
Vieira, L. S.
中科院分区：
文献类型：
--
作者：
Camurca-Vasconcelos, A. L. F.;Bevilaqua, C. M. L.;Vieira, L. S.
由于驱虫药耐药种群的发展，寻找新的药物是必不可少的，以保持生产力的小反刍动物。本研究的目的是评价巴豆和石莲花精油及其主要成分茴香脑和百里酚的驱虫活性。这些油和它们的成分的效果通过体外试验与羊胃肠道线虫捻转血矛线虫的卵和幼虫来确定。以800 mg/kg的剂量对小鼠肠道线虫进行了两种精油的评价。在最后一个实验中，小鼠接受了更大剂量的L。侧突，1200和1600 mg kg（-1）。精油及其成分对H.在1.25mg·ml ~（-1）浓度下，对捻转螺卵的生长抑制率达90%以上。浓度为10 mg/ml（-1）时的捻转幼虫发育。在800 mg·kg ~（-1）浓度下，两种精油对锥虫和四翅无刺线虫的防效分别为46.3%和11.64%。在1200和1600 mg kg（-1）时，L.西得木挥发油对小白鼠的驱虫效果分别为57.6%和68.9%。L. sidoides精油对小鼠肠道线虫的有效性几乎为70%，这表明它应该对绵羊和山羊的胃肠道线虫进行评估。(C)2007年由Elsevier B. V.出版。
Because of the development of anthelmintic resistant populations, the search for new drugs is essential to maintain the productivity of small ruminants. The aim of this study was to evaluate the anthelmintic activity of Croton zehntneri and Lippia sidoides essential oils and their major constituents, anethole and thymol. The effects of these oils and their constituents were determined by in vitro assays with the eggs and larvae of the sheep gastrointestinal nematode Haemonchus contortus. The two essential oils were evaluated on intestinal nematodes of mice at 800 mg kg(-1) dose. In the last experiment, the mice were treated with larger doses of L. sidoides, 1200 and 1600 mg kg(-1). The essential oils and their constituents prevented more than 98% of the H. contortus eggs from hatching at a concentration of 1.25 mg ml(-1) and inhibited more than 90% of H. contortus larval development at a concentration of 10 mg ml(-1). At a concentration of 800 mg kg(-1), the two essential oils were 46.3% and 11.64% effective against Syphacia obvelata and Aspiculuris tetraptera. At 1200 and 1600 mg kg(-1), L. sidoides essential oil's efficacy on the mouse worm burden was 57.6% and 68.9%, respectively. The fact that L. sidoides essential oil was almost 70% effective against mouse intestinal nematodes indicates it should be evaluated against gastrointestinal nematodes of sheep and goats. (C) 2007 Published by Elsevier B.V.