Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome c Oxidase in Traumatic Brain Injury Patients during Hypercapnoea: a Broadband NIRS Study
Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome c Oxidase in Traumatic Brain Injury Patients during Hypercapnoea: a Broadband NIRS Study
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脑外伤患者高碳酸血症期间脑组织细胞色素 c 氧化酶氧化变化分析：宽带 NIRS 研究
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发表时间：
2011
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通讯作者：
Martin Smith
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作者：
I. Tachtsidis;M. Tisdall;C. Pritchard;T. Leung;Arnab Ghosh;C. Elwell;Martin Smith
利用宽带近红外光谱（NIRS）和脑微透析（MD）技术，研究了6例外伤性脑损伤（TBI）患者高碳酸血症后的脑细胞代谢和线粒体氧化还原状态。在所有患者中，经颅多普勒测量的颅内压和脑血流速度升高。尽管脑氧输送可能增加，但我们并没有在每个患者中看到细胞色素-c氧化酶（oxCCO）氧化状态的增加。近红外光谱数据分析显示了两种变化模式；A组（n=4） [oxCCO]增加0.34（±0.34）µM， B组（n=2） [oxCCO]减少0.40（±0.41）µM。虽然Δ[oxCCO]与MD测量的乳酸和丙酮酸浓度变化之间没有明显的关联，但使用模型知情数据解释的进一步工作可能有助于理解在这一异质性患者组中获得的多模态信号。
Using broadband near-infrared spectroscopy (NIRS) and cerebral microdialysis (MD) we investigated cerebral cellular metabolism and mitochondrial redox states, following hypercapnoea in 6 patients with traumatic brain injury (TBI). In all patients hypercapnoea increased intracranial pressure and cerebral blood flow velocity measured with transcranial Doppler. Despite the likely increase in cerebral oxygen delivery, we did not see an increase in the oxidation status of cytochrome-c-oxidase [oxCCO] in every patient. Analysis of the NIRS data demonstrated two patterns of the changes; Group A (n=4) showed an increase in [oxCCO] of 0.34(±0.34)µM and Group B (n=2) a decrease of 0.40(±0.41)µM. Although no obvious association was seen between the Δ[oxCCO] and the MD measured changes in lactate and pyruvate concentrations, further work using model informed data interpretation may be helpful in understanding the multimodal signals acquired in this heterogeneous patient group.