From 'Lab & Light on a Chip' to Parallel Microflow Photochemistry
From 'Lab & Light on a Chip' to Parallel Microflow Photochemistry
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发表时间：
2014
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通讯作者：
O. Shvydkiv
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作者：
M. Oelgemöller;N. Hoffmann;O. Shvydkiv
连续流微反应器为光化学应用提供了主要优势。这篇小型评论总结了詹姆斯库克大学应用与绿色光化学小组及其同事的微流装置的技术发展，从用于微尺度合成的固定微芯片到用于并行光化学的灵活多毛细管系统。封闭式微芯片提供了高时空产率，而开放式毛细管型反应器则显示出进一步修改的更大潜力。因此，构建了 10 微毛细管反应器，并成功用于工艺优化、重现性研究、放大和文库合成。为了证明微流光化学相对于传统间歇工艺的优越性，使用将醇添加到呋喃酮作为模型反应来系统地评估反应器。在所有情况下，微反应器系统都提供了更快的转化、改进的产品质量和更高的产量。在毛细管反应器中示例性地研究了 UVC 诱导的呋喃酮与烯烃的 [2+2] 环加成反应，从而证明了该反应器类型的广泛适用性。
Continuous-flow microreactors offer major advantages for photochemical applications. This mini-review summarizes the technological development of microflow devices in the Applied and Green Photochemistry Group at James Cook University, and its associates, from fixed microchips for microscale synthesis to flexible multicapillary systems for parallel photochemistry. Whereas the enclosed microchip offered high space–time-yields, the open capillary-type reactor showed a greater potential for further modifications. Consequently, a 10-microcapillary reactor was constructed and used successfully for process optimization, reproducibility studies, scale-up, and library synthesis. To demonstrate the superiority of microflow photochemistry over conventional batch processes, the reactors were systematically evaluated using alcohol additions to furanones as model reactions. In all cases, the microreactor systems furnished faster conversions, improved product qualities, and higher yields. UVC-induced [2+2] cycloadditions of furanone with alkenes were exemplarily examined in a capillary reactor, thus proving the broad applicability of this reactor type.