DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol.
DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol.
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DNA链破裂是由神经元NOS的核劫持作为2-甲氧基丙二醇的抗癌作用。
DOI：
10.18632/oncotarget.3913
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发表时间：
2015-06-20
期刊：
影响因子：
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通讯作者：
Wozniak M
中科院分区：
文献类型：
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作者：
Gorska M;Kuban-Jankowska A;Zmijewski M;Marino Gammazza A;Cappello F;Wnuk M;Gorzynik M;Rzeszutek I;Daca A;Lewinska A;Wozniak M
2-甲氧基雌二醇（2-ME）是17β-雌二醇的生理代谢产物。在药理学浓度下，2-ME在肿瘤模型中抑制结肠癌、乳腺癌和肺癌。在这里，我们研究了生理相关浓度的2-ME在骨肉瘤细胞模型中的作用。我们证明，2-ME增加神经元型一氧化氮合酶的核定位，导致硝基氧化DNA损伤。这反过来又导致骨肉瘤细胞的细胞周期停滞和凋亡。我们认为2-ME是一种天然存在的激素，具有潜在的抗癌特性。
2-Methoxyestradiol (2-ME) is a physiological metabolite of 17β-estradiol. At pharmacological concentrations, 2-ME inhibits colon, breast and lung cancer in tumor models. Here we investigated the effect of physiologically relevant concentrations of 2-ME in osteosarcoma cell model. We demonstrated that 2-ME increased nuclear localization of neuronal nitric oxide synthase, resulting in nitro-oxidative DNA damage. This in turn caused cell cycle arrest and apoptosis in osteosarcoma cells. We suggest that 2-ME is a naturally occurring hormone with potential anti-cancer properties.