Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens
Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens
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DOI：
10.1021/np020173x
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发表时间：
2002-12-01
影响因子：
5.1
通讯作者：
Schmidt, JM
中科院分区：
文献类型：
--
作者：
Pettit, GR;Knight, JC;Schmidt, JM
紫丁香假单胞菌的调查冠状病毒抑制肿瘤细胞生长的成分经分离得到2-异丁基-5-(3-吲哚)恶唑(1)和2-正戊基-5-(3-吲哚)恶唑(2f)，分别命名为拉布拉多林1(1)和2(2f)，与胡椒碱(2a)有关。通过光谱分析和X-射线晶体结构测定，确定了化合物的结构。拉布拉多林1(1)对人癌细胞株NCI-H460(肺-NSC)和BXPC-3(胰腺-a)的GI(50)mug/mL值分别为9.8和6.2。
Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI(50) mug/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).