Mortality from primary pulmonary hypertension in the United States, 1979-1996
Mortality from primary pulmonary hypertension in the United States, 1979-1996
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DOI：
10.1378/chest.117.3.796
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发表时间：
2000-03-01
期刊：
影响因子：
9.6
通讯作者：
Rubin, LJ
中科院分区：
文献类型：
--
作者：
Lilienfeld, DE;Rubin, LJ
研究目的：确定1979年以来美国原发性肺动脉高压死亡率是否随着厌氧剂的引入而增加。设计：研究1979 - 1996年美国年龄调整和年龄特异性原发性肺动脉高压的年死亡率，以及1992 - 1996年选定的5个州。研究背景：美国，1979 - 1996年；患者或参与者：美国居民，1979 - 1996年。干预措施:没有。测量和结果：白人男性和女性以及黑人男性和女性的年年龄调整死亡率以不同的速度增加。增幅最大的是黑人女性（她们的发病率也最高）。按年龄划分的死亡率显示，1岁以下的婴儿死亡率高，儿童期死亡率低，在整个生命的其余阶段死亡率呈上升趋势。在州一级也发现了类似的模式。结论：自1979年以来，美国原发性肺动脉高压死亡率显著增加，部分增加可能与引入厌氧剂有关。诊断认识的提高也可以部分解释死亡率上升的原因。这些结果需要在诊断验证研究中得到证实，特别是因为相同的死亡率数据表明，该疾病在老年人中可能比以前报道的更常见。
Study objectives: To determine whether primary pulmonary hypertension mortality in the United States increased since 1979 coincident with the introduction of anorexigens.Design: Examination of annual age-adjusted and age-specific primary pulmonary hypertension mortality in the United States fi om 1979 through 1996 and in fire selected states from 1992 through 1996.Setting: The United States, from 1979 through 1996,Patients or participants: Residents of the United States, from 1979 through 1996.Interventions: None.Measurements and results: Annual age-adjusted mortality increased at different rates among white men and women and black men and women. The greatest increase was among black women (who also had the highest rates). Age-specific mortality showed a high rate among infants < 1 year old, a low rate in childhood, and an ascending rate throughout the remainder of life. Similar patterns were identified at the state level.Conclusions: Primary pulmonary hyper tension mortality in the United States has increased notably since 1979, Some portion of this increase may be related to the introduction of anorexigens. Improvements in diagnostic recognition may also explain part of the increase in mortality. These results need to be confirmed in a diagnosis validation study, particularly because the same mortality data suggest that the disease may he more common in the elderly than has been previously reported.