Short-term consumption of a high-sucrose diet has a pro-oxidant effect in rats
Short-term consumption of a high-sucrose diet has a pro-oxidant effect in rats
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DOI：
10.1079/bjnbjn2002524
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发表时间：
2002-04-01
影响因子：
3.6
通讯作者：
Rayssiguier, Y
中科院分区：
文献类型：
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作者：
Busserolles, J;Rock, E;Rayssiguier, Y
高果糖饮食在动物模型中产生有害后果的潜在机制尚不清楚。然而，果糖喂养可能会促进氧化损伤。因此，本研究的目的是评估，在断乳大鼠中，高蔗糖饮食与淀粉饮食2周对氧化应激变量的影响。测量血浆脂质水平，并通过尿液和血浆硫代巴比妥酸反应物质（TBARS）评估脂质过氧化反应。在体外脂质过氧化后的组织匀浆中测定了几种组织对过氧化的敏感性。通过测量血浆和心脏维生素E水平，以及心脏超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPX）的活性来评估抗氧化防御变量。血浆三酰甘油升高（P
The underlying mechanisms for the detrimental consequences of a high-fructose diet in animal models are not clear. However, the possibility exists that fructose feeding facilitates oxidative damage. Thus, the aim of the present study was to assess, in weaning rats, the effect of a high-sucrose diet v. starch diet for 2 weeks on oxidative stress variables. Plasma lipid levels were measured and lipid peroxidation was evaluated by urine and plasma thiobarbituric acid-reactive substances (TBARS). The susceptibilities of several tissues to peroxidation were determined in tissue homogenates after in vitro lipid peroxidation. Antioxidant defence variables were evaluated by measuring plasma and heart vitamin E levels, and heart superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities. Higher plasma triacylglycerol (P