Growth hormone secretagogues: focus on the growth hormone-releasing peptides.
Growth hormone secretagogues: focus on the growth hormone-releasing peptides.
复制标题
生长激素促分泌素：关注生长激素释放肽。
DOI：
10.1006/phrs.1997.0253
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发表时间：
1997
影响因子：
9.3
通讯作者：
A. Torsello
中科院分区：
文献类型：
--
作者：
Vittorio Locatelli;A. Torsello
这篇综述系统地分析了生长激素释放肽生物学的最新知识。在天然GHRH被分离和测序的许多年前，脑啡肽类似物的合成，缺乏任何阿片类药物活性，但能够特异性地从体外垂体释放GH，促使设计了许多结构相关的ghrp，提高GH释放活性。目前，ghrp是已知的最有效的GH分泌剂，可以有效地用于生长激素分泌障碍患者，促进生长激素分泌模式，以比外源性给药更好的方式模拟生理。
This review systematically analyses recent knowledge of the biology of the growth hormone-releasing peptides. Many years before native GHRH had been isolated and sequenced, the synthesis of an enkephalin analog, devoid of any opioid activity but capable of specifically releasing GH from in vitro pituitaries, prompted the design of a number of structurally interrelated GHRPs with improved GH-releasing activity. Nowadays, GHRPs are the most effective GH-secretagogues known and could be used profitably in humans with GH hyposecretory disturbances to promote a pattern of GH secretion that mimics physiology in a better way than the exogenously administered GH.