Nosocomial methicillin-resistant and methicillin-susceptible, Staphylococcus aureus primary bacteremia:: At what costs
Nosocomial methicillin-resistant and methicillin-susceptible, Staphylococcus aureus primary bacteremia:: At what costs
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DOI：
10.1086/501641
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发表时间：
1999-06-01
影响因子：
4.5
通讯作者：
Sexton, DJ
中科院分区：
文献类型：
--
作者：
Abramson, MA;Sexton, DJ
目的：确定医院内甲氧西林敏感金黄色葡萄球菌 (MSSA) 和耐甲氧西林金黄色葡萄球菌 (MRSA) 原发性血流感染 (BSI) 的住院时间和费用。设计：配对 (1:1) 巢式病例对照研究。销售：大学三级医疗中心。患者：1993 年 12 月至1995年3月获得资格。病例定义为原发性院内金黄色葡萄球菌 BSI 患者；根据先验匹配标准选择对照。测量：住院时间以及住院的总和可变直接费用。结果：原发性院内 MSSA BSI 的中位住院时间为 4 天，而 MRSA 的中位住院时间为 12 天（P=.023）。 MSSA 原发性院内 BSI 的归因中位总费用为 9,661 美元，而 MRSA 院内感染为 27,083 美元 (P=0.043)。结论：金黄色葡萄球菌引起的院内原发性 BSI 显着延长了住院时间。与 MSSA 引起的原发性院内 BSI 相比，MRSA 引起的原发性院内 BSI 导致直接成本增加约三倍（Infect Control Hosp Epidemiol 1999；20：408-411）。
OBJECTIVE: To determine the attributable hospital stay and costs for nosocomial methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S aureus (MRSA) primary bloodstream infections (BSIs).DESIGN: Pairwise-matched (1:1) nested case-control study.SELLING: University-based tertiary-care medical center.PATIENTS: Patients admitted between December 1993 and March 1995 were eligible. Cases were defined as patients with a primary nosocomial S aureus BSI; controls were selected according to a priori matching criteria.MEASUREMENTS: Length of hospital stay and total and variable direct costs of hospitalization.RESULTS: The median hospital stay attributable to primary nosocomial MSSA BSI was 4 days, compared with 12 days for MRSA (P=.023). Attributable median total cost for MSSA primary nosocomial BSIs was $9,661 versus $27,083 for MRSA nosocomial infections (P=.043).CONCLUSION: Nosocomial primary BSI due to S aureus significantly prolongs the hospital stay. Primary nosocomial BSIs due to MRSA result in an approximate threefold increase in direct cost, compared with those due to MSSA (Infect Control Hosp Epidemiol 1999;20:408-411).