Iridium- 191 angiocardiography for the detection and quantitation of left-to-right shunting.
Iridium- 191 angiocardiography for the detection and quantitation of left-to-right shunting.
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Iridium-191 心血管造影用于检测和定量左向右分流。
DOI：
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发表时间：
1980
影响因子：
9.3
通讯作者：
W. Norwood
中科院分区：
文献类型：
--
作者：
S. Treves;C. Cheng;A. Samuel;R. Lambrecht;B. Babchyck;R. Zimmerman;W. Norwood
研制了一种锇- 191生成铱- 191的发生器，该发生器可为首次放射性核素血管造影提供多剂量的铱- 191。铱- 191m的物理半衰期为4.96秒，衰变时发射65 kev和129 kev的光子，丰度分别为58%和30%。使用伽玛相机，对犬和10例患者进行Ir- 191m放射性核素血管造影，以检测和定量左向右分流。在一名一岁的患者中，25mci的Ir- 191m导致全身辐射吸收剂量为35mrad。多个Ir- 191m血管造影可以进行，秒至分钟的间隔，没有干扰的背景。o - 191的半衰期为15.4天，因此可以将发生器运送到远离生产设施的中心。由于放射性核素血管造影具有低辐射剂量、高信息密度、可与Ir- 191m重复研究的特点，应扩大其临床应用。
An osmium- 191 leads to iridium- 191 generator that can deliver multiple doses of Ir- 191m for first-pass radionuclide angiography has been developed. Iridium- 191m has a physical half-life of 4.96 sec and decays with emission of 65-keV and 129-keV photons in 58 and 30% abundance, respectively. Using a gamma camera, Ir- 191m radionuclide angiography was carried out, in dogs and ten patients, for the detection and quantitation of left-to-right shunting. In a one-year-old patients, 25 mCi of Ir- 191m results in a whole-body radiation absorbed dose of 35 mrad. Multiple Ir- 191m angiograms can be performed, seconds to minutes apart, without interference from background. The 15.4-day half-life of Os- 191 permits transportation of the generator to centers far from the production facility. With the low radiation dose, high information density, and the ability to repeat studies with Ir- 191m, clinical use of radionuclide angiography should be expanded.