PAQR proteins: A novel membrane receptor family defined by an ancient 7-transmembrane pass motif
PAQR proteins: A novel membrane receptor family defined by an ancient 7-transmembrane pass motif
复制标题
DOI：
10.1007/s00239-004-0375-2
复制
发表时间：
2005-09-01
影响因子：
3.9
通讯作者：
Funk, WD
中科院分区：
文献类型：
--
作者：
Tang, YT;Hu, TH;Funk, WD
一系列新的论文已经确定了新的受体蛋白，它们可以预测七跨膜的拓扑结构。我们将这个家族整合为11个人类基因，并以最初描述的两个配体(孕激素和ADIPOQ受体)命名为PAQR家族。这个蛋白质家族有着古老的进化根源，在真细菌中发现了已确定的同源物。到目前为止，已发表的数据表明，该家族的原核成员似乎编码溶血素型蛋白，而在真核生物中，PAQR蛋白编码具有广泛配体特异性的功能性受体。我们提供了这个家族的完整的人类和小鼠的互补基因，提出了一个保守的结构/拓扑结构和不变的细胞内氨基酸残基，并测量了这些基因在一系列人类组织中的mRNA表达水平。
An emerging series of papers has identified new receptor proteins that predict seven-transmembrane pass topologies. We have consolidated this family to 11 human genes and have named the family PAQR, after two of the initially described ligands (progestin and adipoQ receptors). This protein family has ancient evolutionary roots, with identified homologs found in eubacteria. To date, published data indicate that the prokaryotic members of this family appear to encode hemolysin-type proteins, while in eukaryotes, PAQR proteins encode functional receptors with a broad range of apparent ligand specificities. We provide the complete human and mouse complement of this family, suggest a conserved structure/topology with invariant intracellular amino acid residues, and have measured mRNA expression levels for these genes across a range of human tissues.