Spontaneous and evoked activity of neurons in deep structures of the brain during their anodal polarization
Spontaneous and evoked activity of neurons in deep structures of the brain during their anodal polarization
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大脑深层结构中神经元在阳极极化过程中的自发活动和诱发活动
DOI：
10.1007/bf01191456
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发表时间：
1986
影响因子：
--
通讯作者：
A. N. Litvinova
中科院分区：
文献类型：
--
作者：
E. Lukhanina;A. N. Litvinova
研究了听觉刺激时阳极极化对尾状核、内侧膝状体和丘脑正中中枢神经元自发活动的影响以及对内侧膝状体神经元诱发冲动活动的影响。用玻璃和金属微电极在细胞外记录脉冲活动。将直径为0.2 mm、末端未绝缘为0.3 mm的镍铬合金极化电极插入上述结构中的包中。测定引起自发和诱发神经元活动可逆抑制的电流参数：在距离极化电极最多3 mm处暴露1 - 3 min期间为300 - 500 μ A。极化停止后，诱发放电抑制持续4-10 min，诱发脉冲反应消失5-20 min。
The influence of anodal polarization on the spontaneous activity of neurons in the caudate nucleus, medial geniculate body, and the median center of the thalamus and on the evoked impulse activity of neurons in the medial geniculate body was investigated during auditory stimulation. The impulse activity was recorded extracellularly with glass and metallic microelectrodes. Nichrome polarizing electrodes of 0.2 mm diameter with an uninsulated tip of 0.3 mm were inserted into the foregoing structures in a packet. Current parameters evoking the reversible suppression of spontaneous and evoked neuronal activity were determined: 300–500 μA during exposure for 1–3 min at a distance of up to 3 mm from the polarizing electrode. After the cessation of polarization, a prolonged aftereffect was observed: The inhibition of evoked discharges lasted 4–10 min, and the evoked impulse responses disappeared for 5–20 min.