Prevention of adriamycin toxicity.
Prevention of adriamycin toxicity.
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预防阿霉素毒性。
DOI：
10.1007/bf00254252
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发表时间：
1983
影响因子：
3
通讯作者：
Bachur,NR
中科院分区：
文献类型：
--
作者：
Banks,AR;Jones,T;Koch,TH;Friedman,RD;Bachur,NR
用致死剂量阿霉素（A1） （IP）治疗的小鼠，用单剂量的3,5,5-三甲基-2- morpholin1 -3-酰基自由基二聚体（TM3）拯救。体内的拯救被认为类似于TM3与A1的体外反应，产生无毒的7-脱氧阿霉素（7dAone）。如果在A1给药后60分钟内给予TM3，则可防止死亡。对照a1处理小鼠在8天内死亡（中位生存时间），而TM3拯救a1处理小鼠的中位生存时间大于60天。
Mice treated with lethal doses of adriamycin (A1) (IP) are rescued with a single IP dose of 3,5,5-trimethyl-2-morpholinon-3-yl radical dimer (TM3). The in vivo rescue is assumed to be analogous to the in vitro reaction of TM3 with A1 that produces the non-toxic 7-deoxy-adriamycinone (7dAone). TM3 prevents death if given within 60 min following A1 administration. Control A1-treated mice died by 8 days (median survival time) whereas TM3 rescued A1-treated mice had a median survival time of greater than 60 days.