Distinctive heavy metal composition of pancreatic juice in patients with pancreatic carcinoma
Distinctive heavy metal composition of pancreatic juice in patients with pancreatic carcinoma
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DOI：
10.1158/1055-9965.epi-07-0332
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发表时间：
2007-12-01
影响因子：
3.8
通讯作者：
Miller, Laurence J.
中科院分区：
文献类型：
--
作者：
Carrigan, Patricia E.;Hentz, Joseph G.;Miller, Laurence J.
流行病学研究表明，暴露于香烟烟雾和空气污染的健康风险，重金属成分被认为是两者的原因。在流行病学上，暴露于香烟烟雾的环境与胰腺癌有关，但其病理生理学基础尚不清楚。在目前的工作中，我们已经使用电感耦合等离子体质谱定量的金属组成的胰液收集在连续的患者评价腹痛（35例胰腺癌，30例慢性胰腺炎，35例正常胰腺）的分泌素刺激。事实上，胰腺癌患者的胰液金属成分与非胰腺癌患者不同。发现与胰腺癌相关性最强的金属浓度是铬、硒和钼，相对于正常胰腺患者，每种浓度增加1 SD，患胰腺癌的几率显著增加（分别为210%、160%和76%）。值得注意的是，铬和硒浓度的升高在个体中并不相关，而那些在胰液中这两种金属浓度总和增加1 SD的人患胰腺癌的几率增加了480%。镍和锌的升高与个体中铬的升高相关，已知这些金属中的每一种都存在于香烟烟雾中，而香烟烟雾中其他公认的金属成分没有升高。了解为什么这些金属在胰液中升高以及它们对胰腺细胞的影响可能对胰腺癌的诊断，治疗甚至预防具有重要意义。
Epidemiologic studies have shown the health risks of exposure to cigarette smoke and air pollution, with heavy metal composition implicated as contributing to both. Environmental exposure to cigarette smoke has been epidemiologically associated with pancreatic cancer, but the pathophysiologic basis for this is not yet clear. In the current work, we have used inductively coupled plasma mass spectrometry to quantify the metal composition of pancreatic juice collected in response to secretin stimulation in successive patients evaluated for abdominal pain (35 with pancreatic cancer, 30 with chronic pancreatitis, and 35 with normal pancreas). Indeed, metal composition of pancreatic juice was distinctive in patients with pancreatic cancer relative to those without such a cancer. The metal concentrations that were found to have the strongest association with pancreatic cancer were chromium, selenium, and molybdenum, with 1 SD increases in the concentrations of each associated with substantial increases in the odds of having pancreatic cancer relative to those in patients with normal pancreas (210%, 160%, and 76%, respectively). Of note, elevations in concentrations of chromium and selenium did not correlate in individuals, whereas those having a 1 SD increase in the sum of the concentrations of these two metals in their pancreatic juice had a 480% increase in the odds of having pancreatic cancer. Elevations of nickel and zinc correlated with elevated chromium in individuals, with each of these metals known to be present in cigarette smoke, whereas other recognized metal components of cigarette smoke were not elevated. An understanding of why these metals are elevated in pancreatic juice and what effects they might have on pancreatic cells may have important implications for the diagnosis, treatment, and even prevention of pancreatic cancer.