Enantioselective rhodium-catalysed addition of boronic acids using C2-symmetric aryl diphosphite ligands
Enantioselective rhodium-catalysed addition of boronic acids using C2-symmetric aryl diphosphite ligands
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DOI：
10.1016/s0022-328x(03)00349-8
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发表时间：
2003-08-29
影响因子：
2.3
通讯作者：
Frost, CG
中科院分区：
文献类型：
--
作者：
Chapman, CJ;Wadsworth, KJ;Frost, CG
在c -2对称芳基二亚磷酸酯配体（R，R,R-4）的存在下，成功地进行了芳基硼酸与脱氢丙氨酸衍生物的对映选择性铑催化共轭加成，制备了非天然氨基酸酯。产品的ee含量高达72%，分离收率良好。(C) 2003 Elsevier Science B.V.版权所有
The enantioselective rhodium-catalysed conjugate addition of aryl boronic acids to dehydroalanine derivatives has been successfully carried out in the presence of C-2-symmetric aryl diphosphite ligand (R,R,R-4) to prepare unnatural amino acid esters. The products have been obtained in up to 72% ee and with good isolated yield. (C) 2003 Elsevier Science B.V. All rights reserved.