Intersecting pathways in cell biology.
Intersecting pathways in cell biology.
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DOI：
10.1126/scisignal.3152re10
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发表时间：
2010-12-14
影响因子：
7.3
通讯作者：
O'Bryan JP
中科院分区：
文献类型：
--
作者：
O'Bryan JP
The endocytic pathway is involved in activation and inhibition of cellular signaling. Thus, defining the regulatory mechanisms that link endocytosis and cellular signaling is of interest. An emerging link between these processes is a family of proteins called intersectins (ITSNs). These multi-domain proteins serve as scaffolds in the assembly of endocytic vesicles, and also regulate components of various signaling pathways, including kinases, GTPases, and ubiquitin ligases. This review will summarize research on the role of ITSNs in regulating both endocytic and signal transduction pathways, discuss the link of ITSNs with human disease, and highlight future directions in the study of ITSNs.
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