Prognostic significance of osteopontin in acute myeloid leukemia: A meta-analysis
Prognostic significance of osteopontin in acute myeloid leukemia: A meta-analysis
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DOI：
10.3892/mco.2017.1302
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发表时间：
2017-08-01
影响因子：
1.2
通讯作者：
Du, Zhongli
中科院分区：
文献类型：
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作者：
Chen, Yong-Bing;Ren, Si-Mei;Du, Zhongli
骨桥蛋白（OPN）在肿瘤研究领域已被研究多年。然而，OPN过度表达在急性髓系白血病（AML）中的预后作用仍存在争议。对4项研究（共492例患者）进行荟萃分析，以确定OPN与AML患者总生存期（OS）的相关性。使用Der Simonian和Laird的随机效应模型合成数据;使用风险比（HR）及其95%置信区间（CI）作为效应量估计值。血清OPN水平与OS呈负相关，差异有统计学意义（HR=1.83，95%CI：1.43-2.35; P
Osteopontin (OPN) has been investigated in the field of tumor research for several years. However, the prognostic role of OPN over-expression in acute myeloid leukemia (AML) remains controversial. A meta-analysis of four studies, including a total of 492 patients, was performed to determine the association of OPN with overall survival (OS) in AML patients. The random-effects model of Der Simonian and Laird was used to synthesize data; hazard ratio (HR) with its 95% confidence interval (CI) was used as the effect size estimate. It was observed that serum-based OPN was inversely correlated with OS and the difference was statistically significant (HR=1.83; 95% CI: 1.43-2.35; P