New experimental models of the blood-brain barrier for CNS drug discovery.
New experimental models of the blood-brain barrier for CNS drug discovery.
复制标题
CNS药物发现的血脑屏障的新实验模型。
DOI：
10.1080/17460441.2017.1253676
复制
发表时间：
2017-01
影响因子：
6.3
通讯作者：
Cucullo L
中科院分区：
文献类型：
--
作者：
Kaisar MA;Sajja RK;Prasad S;Abhyankar VV;Liles T;Cucullo L
血脑屏障（BBB）是一个动态的生物界面，它主动控制血液和中枢神经系统（CNS）之间物质的通过。从生物学和功能的角度来看，血脑屏障在维持大脑稳态中起着至关重要的作用，因为血脑屏障功能的恶化是许多中枢神经系统疾病的前驱症状。相反，血脑屏障阻碍了针对大脑治疗各种神经系统疾病的药物的输送。本文回顾了BBB建模领域的最新技术改进和创新，包括静态和动态细胞平台，微流体系统以及干细胞和3D打印技术的使用。此外，作者为微流体和干细胞生物学的整合制定了路线图，作为开发新型体外血脑屏障平台的整体方法。由于缺乏在体外模拟血脑屏障和脑血管损伤的可靠策略，有效的中枢神经系统药物的开发一直受到阻碍。血脑屏障建模的技术进步促进了高度整合和准生理的体外平台的发展，以支持药物发现的过程。这些先进的体外工具可能会进一步了解脑血管调节机制。
The blood-brain barrier (BBB) is a dynamic biological interface which actively controls the passage of substances between the blood and the central nervous system (CNS). From a biological and functional standpoint, the BBB plays a crucial role in maintaining brain homeostasis inasmuch that deterioration of BBB functions are prodromal to many CNS disorders. Conversely, the BBB hinders the delivery of drugs targeting the brain to treat a variety of neurological diseases. This article reviews recent technological improvements and innovation in the field of BBB modeling including static and dynamic cell-based platforms, microfluidic systems and the use of stem cells and 3D printing technologies. Additionally, the authors laid out a roadmap for the integration of microfluidics and stem cell biology as a holistic approach for the development of novel in vitro BBB platforms. Development of effective CNS drugs has been hindered by the lack of reliable strategies to mimic the BBB and cerebrovascular impairments in vitro. Technological advancements in BBB modeling have fostered the development of highly integrative and quasi- physiological in vitro platforms to support the process of drug discovery. These advanced in vitro tools are likely to further current understanding of the cerebrovascular modulatory mechanisms.
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DOI：
10.1602/neurorx.2.4.554
发表时间：
2005-10-01
期刊：
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics
影响因子：
--
作者：
Alavijeh, Mohammad S;Chishty, Mansoor;Palmer, Alan M
通讯作者：
Palmer, Alan M
DOI：
10.1007/978-1-60761-938-3_13
发表时间：
2011-01-01
期刊：
BLOOD-BRAIN AND OTHER NEURAL BARRIERS: REVIEWS AND PROTOCOLS
影响因子：
--
作者：
Cayrol, Romain;Haqqani, Arsalan S.;Prat, Alexandre
通讯作者：
Prat, Alexandre
影响因子：
3.3
作者：
Augustine, C.;Cepinskas, G.;Fraser, D. D.
通讯作者：
Fraser, D. D.
影响因子：
3.7
作者：
Cecchelli R;Aday S;Sevin E;Almeida C;Culot M;Dehouck L;Coisne C;Engelhardt B;Dehouck MP;Ferreira L
通讯作者：
Ferreira L
影响因子：
3.7
作者：
Boyer-Di Ponio J;El-Ayoubi F;Glacial F;Ganeshamoorthy K;Driancourt C;Godet M;Perrière N;Guillevic O;Couraud PO;Uzan G
通讯作者：
Uzan G