Death rates in the U.S. due to Krabbe disease and related leukodystrophy and lysosomal storage diseases
Death rates in the U.S. due to Krabbe disease and related leukodystrophy and lysosomal storage diseases
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DOI：
10.1002/ajmg.a.35624
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发表时间：
2012-11-01
影响因子：
2
通讯作者：
Carter, Randy L.
中科院分区：
文献类型：
--
作者：
Barczykowski, Amy L.;Foss, Alexander H.;Carter, Randy L.
脑白质营养不良（LD）和溶酶体贮积症（LSD）作为新生儿筛查计划的目标，最近引起了越来越多的关注。在美国，需要准确的流行病学基准。对克拉伯病（KD）和9种相关疾病的特定死亡率进行了估计。1999 - 2004年期间，美国死亡率记录与E75.2死因代码收集了11个开放记录的国家。根据在这些州观察到的比例，美国所有E75.2死亡病例均分布在特定疾病类型中。从CDC获得年度种群大小并取平均值。按年龄组分列的特定疾病的死亡率（每年每百万人）为（2000年）
Leukodystrophies (LD) and lysosomal storage disorders (LSD) have generated increased interest recently as targets for newborn screening programs. Accurate epidemiological benchmarks are needed in the U.S. Age-specific mortality rates were estimated for Krabbe disease (KD) and nine related disorders. U.S. mortality records with E75.2 cause of death code during 19992004 were collected from 11 open record states. All E75.2 deaths in the United States were distributed into specific disease type based on proportions observed in these states. Yearly population sizes were obtained from the CDC and averaged. Mortality rates (per million individuals per year) by age group for the specific diseases were (for