Cancer invasion and metastasis
Cancer invasion and metastasis
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DOI：
10.1159/000086626
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发表时间：
2005-01-01
期刊：
影响因子：
3.5
通讯作者：
Neid, M
中科院分区：
文献类型：
--
作者：
Wittekind, C;Neid, M
转移是恶性肿瘤从一个器官转移到远处器官。它是癌症患者死亡的最常见原因。不同的分子机制使肿瘤细胞能够渗透周围组织，侵入血管并在不同部位离开血流。肿瘤细胞与细胞外基质成分的相互作用、上皮-间质转化以及血管生成是肿瘤侵袭和转移的重要因素。不同器官中转移细胞的基因表达谱是不同的，并且不是每个肿瘤细胞都具有转移的能力。器官中的微环境影响转移的形成。只有1%的微转移进展为大转移。版权所有（C）2005 S. Karger AG，巴塞尔。
Metastasis is the transfer of malignant tumors from one organ to a distant organ. It is the most common cause of death in cancer patients. Different molecular mechanisms enable tumor cells to infiltrate the surrounding tissue, invade blood vessels and leave the blood stream at a different site. Tumor cell interaction with extracellular matrix components and epithelial-mesenchymal transition as well as angiogenesis are important factors in invasion and metastasis. Gene expression profiles of metastatic cells in various organs are different and not every tumor cell has the capacity to metastasize. The microenvironment in the organ influences formation of metastasis. Only 1% of micrometastases progress into macrometastases. Copyright (C) 2005 S. Karger AG, Basel.