Creutzfeldt-Jakob disease with dizziness initially presenting to the otolaryngology department
Creutzfeldt-Jakob disease with dizziness initially presenting to the otolaryngology department
复制标题
克雅氏病伴头晕，最初就诊于耳鼻喉科
DOI：
10.1016/j.anl.2022.04.005
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发表时间：
2023
影响因子：
1.7
通讯作者：
Matsumoto Fumihiko
中科院分区：
文献类型：
--
作者：
Hara Satoshi;Inoshita Ayako;Miyamoto Nobukazu;Takata Yusuke;Matsuoka Rina;Anzai Takashi;Nakamura Masahiro;Ikeda Katsuhisa;Matsumoto Fumihiko
克雅氏病是一种致命的中枢神经系统传染性朊病毒病。头晕作为克雅氏病的初始表现是罕见的。然而，患有克雅氏病和头晕的患者最初可能会去耳鼻喉科就诊，但这并不常见。我们报告的情况下，56岁的妇女与克雅氏病谁最初提出了头晕作为急诊病人的耳鼻喉科。使用红外照明的电荷耦合器件照相机识别原发位置上跳性眼球震颤。眼震电图显示平滑追踪受损，视动性眼震减少。根据这些发现，我们立即怀疑头晕的颅内原因，并初步诊断为散发性克雅氏病，从而防止了严重的传播。本病例强调，克雅氏病应被纳入头晕和异常眼球运动患者的鉴别诊断，如原发位置上拍性眼球震颤，这可能是由颅内疾病引起的。
Creutzfeldt-Jakob disease is a fatal transmissible prion disease of the central nervous system. Dizziness as an initial manifestation of Creutzfeldt-Jakob disease is rare. However, patients with Creutzfeldt-Jakob disease and dizziness may initially visit the otolaryngology department, but this is uncommon. We report the case of a 56-year-old woman with Creutzfeldt-Jakob disease who initially presented with dizziness as an emergency patient to the otolaryngology department. Primary position upbeat nystagmus was identified using a charge-coupled device camera with infrared illumination. Electronystagmography revealed impaired smooth pursuit and diminished optokinetic nystagmus. Based on these findings, we immediately suspected an intracranial cause of dizziness and reached a presumptive diagnosis of sporadic Creutzfeldt-Jakob disease, thus preventing severe transmission. This case emphasizes that Creutzfeldt-Jakob disease should be included as a differential diagnosis for patients with dizziness and abnormal eye movements, such as primary position upbeat nystagmus, which might be caused by intracranial disease.