The ability of bacterial lipopolysaccharide to modulate the induction of unresponsiveness to a state of immunity. Cellular parameters.
The ability of bacterial lipopolysaccharide to modulate the induction of unresponsiveness to a state of immunity. Cellular parameters.
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DOI：
10.1084/jem.138.6.1481
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发表时间：
1973-12-01
期刊：
影响因子：
--
通讯作者：
Weigle WO
中科院分区：
文献类型：
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作者：
Louis JA;Chiller JM;Weigle WO
进行研究以确定细菌脂多糖（LPS）干扰诱导对人γ球蛋白（HGG）免疫无反应性的细胞参数。用解聚的HGG（耐受原）和LPS注射的小鼠没有变得对该抗原耐受，而是变得对随后用免疫原的攻击致敏。在过继转移系统中也证明了用耐受原和LPS引发的能力。注射耐受原和注射LPS之间的时间关系对于引发的发生至关重要。注射耐受原和LPS不仅引发小鼠对HGG，而且还导致对HGG的初级抗体应答。LPS干扰耐受诱导的能力仅限于B细胞，并不影响T细胞诱导无反应性的能力。在由耐受原和LPS引发的小鼠中，发现对HGG的次级应答是T细胞非依赖性的。这些观察结果进行解释和讨论的LPS的能力，以规避所需的T细胞的合作，并调制成免疫原性信号致耐受性刺激的立场。
Studies were performed to define the cellular parameters involved in the interference with the induction of immunologic unresponsiveness to human gamma globulin (HGG) by bacterial lipopolysaccharide (LPS). Mice which were injected with deaggregated HGG (tolerogen) and with LPS did not become tolerant to that antigen, but rather became primed to a subsequent challenge with immunogen. The ability to prime with tolerogen and LPS was also demonstrated in an adoptive transfer system. The temporal relationship between the injection of tolerogen and that of LPS was critical for priming to occur. The injection of tolerogen and LPS not only primed mice to HGG, but also resulted in a primary antibody response to HGG. The capacity of LPS to interfere with the induction of tolerance was restricted to B cells and did not affect the ability to induce unresponsiveness in T cells. The secondary response to HGG in mice primed by tolerogen and LPS was found to be T-cell independent. These observations are interpreted and discussed from the standpoint of the ability of LPS to circumvent required T-cell cooperation and to modulate to tolerogenic stimulus into an immunogenic signal.