Transcriptome analysis reveals immune pathways underlying resistance in the common carp Cyprinus carpio against the oomycete Aphanomyces invadans.
Transcriptome analysis reveals immune pathways underlying resistance in the common carp Cyprinus carpio against the oomycete Aphanomyces invadans.
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DOI：
10.1016/j.ygeno.2020.10.028
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发表时间：
2020-10
期刊：
影响因子：
4.4
通讯作者：
D. K. Verma;L. Peruzza;L. Peruzza;F. Trusch;F. Trusch;M. Yadav;Ravindra;Sergei V. Shubin;K. Mo
中科院分区：
文献类型：
--
作者：
D. K. Verma;L. Peruzza;L. Peruzza;F. Trusch;F. Trusch;M. Yadav;Ravindra;Sergei V. Shubin;K. Mo
入侵丝囊菌感染是一种严重的鱼类疾病，具有重大的全球性影响。尽管影响超过160种鱼类，但一些物种，如鲤鱼，对A。本研究对实验感染A.入侵者在时间进程分析中，发现了5288个差异表达基因（DEG），其中731个涉及21个免疫途径。免疫相关DEG的分析表明，A.入侵抗原、增强的吞噬作用、病原体相关分子模式的识别以及白细胞向感染部位的募集增加有助于鲤鱼对A.入侵者在此，我们提供了一个系统的了解，在普通鲤鱼的抗病机制在分子水平上作为一个宝贵的资源，制定疾病管理策略，这种毁灭性的鱼类致病卵菌。
Infection withAphanomyces invadansis a serious fish disease with major global impacts. Despite affecting over 160 fish species, some of the species like the common carpCyprinus carpioare resistant toA. invadansinfection.In the present study, we investigated the transcriptomes of head kidney of common carp experimentally infected withA. invadans. In time course analysis, 5288 genes were found to be differentially expressed (DEGs), of which 731 were involved in 21 immune pathways. The analysis of immune-related DEGs suggested that efficient processing and presentation ofA. invadansantigens, enhanced phagocytosis, recognition of pathogen-associated molecular patterns, and increased recruitment of leukocytes to the sites of infection contribute to resistance of common carp againstA. invadans. Herein, we provide a systematic understanding of the disease resistance mechanisms in common carp at molecular level as a valuable resource for developing disease management strategies for this devastating fish-pathogenic oomycete.