Expression of macrophage inflammatory protein 3α in human inflamed dental pulp tissue
Expression of macrophage inflammatory protein 3α in human inflamed dental pulp tissue
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DOI：
10.1097/01.don.0000143414.22112.57
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发表时间：
2005-02-01
影响因子：
4.2
通讯作者：
Matsuo, T
中科院分区：
文献类型：
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作者：
Nakanishi, T;Takahashi, K;Matsuo, T
由龋齿引起的严重牙髓炎的特征是明显的炎性浸润物，如淋巴细胞。关于这些细胞在龋齿牙髓病变中的募集情况知之甚少。巨噬细胞炎性蛋白-3α(MIP-3α)是一种CC趋化因子，可吸引表达CCR6的T细胞。我们用免疫组织化学方法检测了MIP-3α和/或CCR6阳性细胞在人炎症牙髓和正常牙髓中的分布。MIP-3α在所有炎症牙髓切片中均可观察到，且主要分布于邻近龋损区域聚集的巨噬细胞。此外，CCR6在浸润性淋巴细胞中也有表达。相比之下，正常牙髓组织中MIP-3α和CCR6的表达很少。这些发现表明，MIP-3α通过募集表达CCR6的淋巴细胞在促进牙髓炎症中发挥作用。
Severe pulpitis resulting from dental caries is characterized by marked inflammatory infiltrate such as lymphocytes. Little is known about the recruitment of these cells into the dental pulp lesions of carious teeth. Macrophage inflammatory protein-3alpha (MIP-3alpha), a CC chemokine attracts CC chemokine receptor 6 (CCR6)-expressing T cells. We examined the distribution of MIP-3alpha-positive and/or CCR6-positive cells in human inflamed and normal dental pulp by immunohistochemistry. MIP-3alpha was observed in all inflamed pulp sections, and was mostly distributed in macrophages that had accumulated in the area adjacent to carious lesions. Furthermore, CCR6 expression was also observed in the infiltrating lymphocytes. in contrast, MIP-3alpha and CCR6 were rarely detected in normal pulp. These findings suggest that MIP-3alpha plays a role in the advancement of pulpal inflammation via the recruitment of CCR6-expressing lymphocytes.