Transforming growth factor β receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells
Transforming growth factor β receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells
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DOI：
10.1016/j.molbrainres.2003.11.008
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发表时间：
2004-02-05
期刊：
影响因子：
--
通讯作者：
Brown, EM
中科院分区：
文献类型：
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作者：
Chattopadhyay, N;Tfelt-Hansen, J;Brown, EM
转化生长因子（TGF β）和肝细胞生长因子（HGF）促进胶质瘤进展。使用表达TGF β受体（TbetaRs）的U87人星形细胞瘤细胞，我们发现：（1）Smads（2，3，4）、骨形态发生蛋白（BMP）和激活素A受体的mRNA表达;（2）TGF β 1抑制增殖，HGF诱导增殖;（3）TGF β 1和激活素A同等抑制HGF分泌，其抑制作用大于BMP-2，但均未改变c-Met表达。因为干扰TbetaR信号传导可能使HGF分泌的有益抑制无效，所以应考虑将激活素A用于联合胶质瘤治疗。(C)2004 Elsevier B. V.保留所有权利。
Transforming growth factor (TGFbeta) and hepatocyte growth factor (HGF) promote glioma progression. Using U87human astrocytoma cells, which express TGFbeta receptors (TbetaRs), we show (1) mRNA expression of Smads (2, 3, 4), bone morphogenetic protein (BMP)- and activin-A receptors; (2) TGFbeta1 inhibits and HGF induces proliferation; (3) TGFbeta1 and activin-A equipotently inhibit HGF secretion more than BMP-2, but none alters c-Met expression. Because interfering with TbetaR signaling might nullify the beneficial inhibition of HGF secretion, activin-A should instead be considered for combination glioma therapy. (C) 2004 Elsevier B.V. All rights reserved.